Vitamin K1

Vitamin K1

Vitamin K1

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1 Kilogram

Negotiable

  • Min.Order :1 Kilogram
  • Purity: 98%
  • Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Vitamin K184-80-0 84-80-0 manufacturer , better price with good quality

Quick Details

  • Appearance:Yellow Oil
  • Application:Pharmaceuticals
  • PackAge:Depended
  • ProductionCapacity:300|Kilogram|Month
  • Storage:KEEP COLD
  • Transportation:BY SEA OR AIR

Superiority:

Vitamin K1 Basic information
Vitamin K Limited use The maximum allowable amount as food additives and maximum allowable residue limits Chemical Properties Application Production method
Product Name: Vitamin K1
Synonyms: VITAMIN K1;VITAMIN K1(20);VITAMIN K1(25);,r*-(e)))-;[r-[r*,R*-(E)]]-2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-napthalenedione;[r-[r*,R*-(E)]]-2-Methyl-3-(3-7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione;1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-;1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-, [R-[R*,R*-(E)]]-
CAS: 84-80-0
MF: C31H46O2
MW: 450.7
EINECS: 201-564-2
Product Categories: Biochemistry;Vitamins;Vitamins and derivatives;Drugs & Medication;Vitamin Ingredients;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Retinoids;AQUAMEPHYTON;Isolabel;Other APIs;Inhibitors
Mol File: 84-80-0.mol
Vitamin K1 Structure
 
Vitamin K1 Chemical Properties
mp  −20 °C(lit.)
bp  140°C 0mm
density  0.984 g/mL at 25 °C(lit.)
refractive index  n20/D 1.527(lit.)
Fp  >230 °F
storage temp.  2-8°C
form  viscous liquid
Sensitive  Light Sensitive
Merck  14,7380
BRN  2568816
CAS DataBase Reference 84-80-0(CAS DataBase Reference)
NIST Chemistry Reference Phytonadione(84-80-0)
EPA Substance Registry System 1,4-Naphthalenedione, 2-methyl-3-[(2E,7R,11R)-3, 7,11,15-tetramethyl-2-hexadecenyl]- (84-80-0)
 
Safety Information
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39
WGK Germany  2
RTECS  QJ5800000
F  1-8-10
Hazardous Substances Data 84-80-0(Hazardous Substances Data)
MSDS Information
Provider Language
ALFA English
 
Vitamin K1 Usage And Synthesis
Vitamin K In 1929, a famous chemist Dam (Denmark) had first discovered and extracted a yellow crystalline substance from animal liver and linseed oil - vitamin K. 
Vitamin K is a the indispensable substance for hepatic synthesis of the four kinds of coagulation factors (active clotting factor Ⅱ (prothrombin), coagulation factor Ⅶ, coagulation factors Ⅺ and coagulation factor Ⅹ). Upon a lack of vitamin K1, the above four coagulation factors synthesized in liver synthesis become abnormal protein molecules while their ability to catalyze clotting effect dropped significantly. It is known that vitamin K is the cofactor for the glutamic acid γ-carboxylation. Lack of vitamin K disables the above γ- carboxylation of coagulation factors; in addition, these types of blood coagulation factors will reduce and will cause blood clotting slowing down and bleeding disorders. In addition, it is generally recognized that vitamin K was dissolved in mitochondrial membrane lipids, playing a role of electron transfer. Vitamin K can increase the intestinal motility and secretion property. Lack of vitamin will cause reduction in the tension and contraction of smooth muscle and can also affect the metabolism of some hormones, such as causing delay of the decomposition of glucocorticoids in the liver. It also has similar effects as hydrocortisone. Long-term injection of vitamin K can increase the thyroid and other endocrine activity.
Vitamin K can be divided into two categories with both of them belonging to 2-methyl-1, 4-naphthoquinone derivatives. One class belongs to fat-soluble vitamins, namely vitamin K1 extracted from green plants (such as alfalfa, spinach and other leafy greens, etc.) and vitamin K2 extracted from microorganisms. Vitamin K2 can also be synthesized by human intestinal bacteria (such as E. coli). Vitamin K1 appears as yellow oil-like liquid while K2 appears pale yellow crystals. Both of them have heat resistance property, but are vulnerable to ultraviolet radiation to be destroyed, and therefore should be stored separately. Another class is water-soluble vitamins, namely artificially synthetic vitamin K3 and K4. The most important vitamins are K1 and K2.
Vitamin K appears as oily liquid or solid and is insoluble in water but soluble in oils and organic solvents such as ether. It is chemically stable with heat and acid resistant, but being susceptible to alkali and UV degradation. The human body has a low demand. However, newborn infants are vulnerable to being lack of vitamin K that is an important vitamin for promoting blood clotting and normal bone growth. Dark green vegetables and yogurt are easily available vitamin K supplements obtained from the daily diet. Human has a very small demand for vitamin K but it is needed to maintain the normal function of blood coagulation, reduce heavy bleeding menstrual period, but also to prevent internal bleeding and hemorrhoids. Patients suffering frequent nosebleeds should be take more vitamin K from natural foods.
This information is edited by Xiongfeng Dai from Chemicalbook.
Limited use Limited GB 14880-94: baby food, 420 ~ 475 μg/ku.
The maximum allowable amount as food additives and maximum allowable residue limits The maximum allowable amount as food additives and maximum allowable residue limits
Chemical Properties It appears as yellow to orange transparent viscous liquid and is odorless with the relative density being 0.967 and the refractive index being nD251.525 ~ 1.528. It is easily soluble in chloroform, ether and vegetable oil, slightly soluble in ethanol and insoluble in water. It is easily to be decomposed when exposed to light and with being decomposed upon being heated to 120 ℃.
Application 1. It can be used as food supplements. It can be used in infant foods with the usage amount being 420 ~ 475μg / kg. 
2. It belongs to vitamin drugs to be used for the prevention and treatment of vitamin K1 deficiency symptom, low thrombin disease and natural newborn hemorrhagic disease.
3. promote blood clotting.
4. promote the synthesis of primary liver thrombin. 
5. increase the intestinal motility and secretion function.
Production method It can be obtained through the following process: o-naphthoquinone is mixed with acetic anhydride to have reduction, acetylation reaction to generate acetylated menadione in the presence of zinc; followed by hydrolysis in ammonia and further condensation reaction with phytol in ether with the catalysis of boron trifluoride to generate dihydro vitamin K1; and finally with hydrolysis, oxidation, purification and refining to derive the products.
Chemical Properties Yellow Oil
Usage vitamin K1
Usage Labeled Phytonadione, intended for use as an internal standard for the quantification of Phytonadione by GC- or LC-mass spectrometry.
Usage Occurs widely in green plants, algae, photosynthetic bacteria.
 
Vitamin K1 Preparation Products And Raw materials
Raw materials Acetic anhydride-->Methylnaphthalene-->METHYL NAPHTHALENE-->PHYTOL

 

Details:

Henan Sunlake Enterprise Corporation is located in Henan Province, the central plain of China , Which enjoys favorable geogeaphical position and convenient transportion. The comany was established in june 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
     Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs ,  Water treatment chemicals , Food & FEED additives and others . These products have been being well exported to Europe , Southeast Asia , the Middle East ,  Africa , South America and some other countries and areas.
    We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team who are professional engineers and scholars with Ph. D. .So we are confident to serve you  better with our high - quality products and professional team.
    We are taking great efforts to provide our customers with demanded goods and professional services, continuously improve our core ability of competition and get the momentum for sustainable development ,Which finally makes us being a reliable and professional supplier in international market.
     We welcome any inquiries from all customers of the world, and sincerely hope to cooperate with you for a brilliant future!
 
Our Advantages:
I). We have abundant professional production experience.
II). We have our own chemical factory.
III). Sample is free of charge.
IV). Reasonable Price, Excellent Quality & Attentive Service
V). Prompt reply: we can reply your inquiry and email within 24 hours.
VI). Fast Delivery: The delivery time is about 10-20 days after receiving the deposit.
VII). We have passed the LFGB, SGS, STC, HSL and some other tests.
VIII). We have a unity cooperation team.
 

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