CAS:224452-66-8 C30H47NO4S RETAPAMULIN CAS:224452-66-8 C30H47NO4S CAS:224452-66-8
RETAPAMULIN Basic information |
Product Name: | RETAPAMULIN |
Synonyms: | RETAPAMULIN;Rebapamulin;SB-275833;RetapaMulin (SB-275833);(3aS,4R,5S,6S,8R,9R,9aR,10R)-2-(exo-8-Methyl-8-azabicyclo[3.2.1]octan-3-ylsulfanyl)acetic acid 5-hydroxy-4,6,9,10-tetraMethyl-1-oxo-6-vinylperhydro-3a,9-propanocyclopentacycloocten-8-yl ester;RetapaMulin API;tetapaMulin;(1S,2R,3S,4S,6R,7R,8R,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetraMethyl-9-oxotricyclo[5.4.3.0^{1,8}]tetradecan-6-yl 2-{[(1R,3S,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl]sulfanyl}acetate |
CAS: | 224452-66-8 |
MF: | C30H47NO4S |
MW: | 517.77 |
EINECS: | |
Product Categories: | API, Antibiotics;Inhibitors |
Mol File: | 224452-66-8.mol |
RETAPAMULIN Chemical Properties |
CAS DataBase Reference | 224452-66-8(CAS DataBase Reference) |
Safety Information |
RETAPAMULIN Usage And Synthesis |
Usage | Retapamulin is a topical antibiotic, which binds to both E. coli and S. aureus ribosomes with similar potencies with Kd of 3 nM |
Usage | Retapamulin is a semi-synthetic pleuormutilin prepared by reacting pleuromutilin tosylate with tropine-3-thiol to give a more hydrophobic analogue with a tertiary amine. This enables formulation as a stable hydrochloride salt. Retapamulin is a broad spectrum antibiotic with no cross resistance to existing antibiotic classes, and is the first pleuromutilin approved for human use. Like all the pleuromutilins, retapamulin inhibits protein synthesis by binding to domain V of 23S rRNA. |
Usage | A broad spectrum antibiotic with no cross resistance to existing classes |
Usage | Retapamulin is a semi-synthetic pleuromutilin prepared by reacting pleuromutilin tosylate with tropine-3-thiol to give a more hydrophobic analogue with a tertiary amine. This enables formulation as a stable hydrochloride salt. Retapamulin is a broad spectrum antibiotic with no cross resistance to existing antibiotic classes, and is the first pleuromutilin approved for human use. Like all the pleuromutilins, retapamulin inhibits protein synthesis by binding to domain V of 23S rRNA. |
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