CAS:550-99-2 C14H15ClN2 Naphazoline hydrochloride
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| 500 Gram |
Negotiable |
- Min.Order :500 Gram
- Purity: 99%
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Keywords
CAS:550-99-2 C14H15ClN2 Naphazoline hydrochloride CAS:550-99-2 C14H15ClN2 CAS:550-99-2
Quick Details
- Appearance:white poweder
- Application:CAS:550-99-2 C14H15ClN2 Naphazoline hydrochloride
- PackAge:Plastic vacuum packaging bag or bucket
- ProductionCapacity:1|Metric Ton|Day
- Storage:under the cool and dry area
- Transportation:by air or by sea
Superiority:
| Naphazoline hydrochloride Basic information |
| Product Name: | Naphazoline hydrochloride |
| Synonyms: | naphconforte;naphthasoliumchloride;niazol;privinehydrochloride;prizolehydrochloride;rhinantin;rhinoperd;sanorin-spofa |
| CAS: | 550-99-2 |
| MF: | C14H15ClN2 |
| MW: | 246.74 |
| EINECS: | 208-989-2 |
| Product Categories: | Adrenoceptor;NORMODYNE;Pharmaceutical intermediates |
| Mol File: | 550-99-2.mol |
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| Naphazoline hydrochloride Chemical Properties |
| mp | 254-260 °C |
| Water Solubility | 170 g/L (20 ºC) |
| Sensitive | Hygroscopic |
| Merck | 14,6368 |
| BRN | 3716843 |
| CAS DataBase Reference | 550-99-2(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | T,Xn |
| Risk Statements | 25-23/24/25-20/21/22 |
| Safety Statements | 45-36/37/39-24/25 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | NJ4375000 |
| HazardClass | 6.1 |
| PackingGroup | III |
| Hazardous Substances Data | 550-99-2(Hazardous Substances Data) |
| MSDS Information |
| Provider | Language |
|---|---|
| 2-(1-Naphthylmethyl)imidazoline hydrochloride | English |
| ACROS | English |
| SigmaAldrich | English |
| ALFA | English |
| Naphazoline hydrochloride Usage And Synthesis |
| Pharmacological effects |
Naphazoline hydrochloride, is commonly used as a vasoconstrictor in the hospital's otorhinolaryngology and ophthalmology ,it is a adrenomimetic drug ,it has a strong effect on contraction of blood vessels and blood pressure elevation,it has inhibition effect on the central nervous system,by contraction of local vascular, it can play an anti-inflammatory and analgesic role in the local inflammatory lesions , and can eliminate congestion due to fatigue or other reasons. Clinically it is used for the treatment of colds, acute and chronic rhinitis, allergic conjunctivitis, allergic and inflammatory nasal congestion embolism. Local long-term use can lead to blood flow reduction in medication area, which causes resistance decreasing , and results in superinfection. It can not be taken orally. Dropping excess liquid or high concentrations can cause poisoning. Care should be taken, especially in children. Infants, hypertension, hyperthyroidism patients should take with caution, atrophic rhinitis patients are banned. The interval time of dropping , is preferably not less than 4 to 6 hours. The above information is edited by the chemicalbook of Tian Ye. |
| Chemical Properties | White crystalline powder. Melting point 255-260 ℃. 40 grams of the product can be dissolved in 100 ml of water . It is soluble in alcohol, slightly soluble in chloroform, insoluble in ether and benzene. Odorless, bitter taste. |
| Application | This product is a vasoconstrictor. Rat subcutaneous injection is LD50 385 mg / kg. |
| Production method | By the α- naphthalene acetic acid and ethylene diamine condensation, cyclization ,2- (1-naphthylmethyl) imidazoline (C14H14N2, [835-31-4]) is made , then after salifying, naphazoline hydrochloride is derived . The α- acetic acid and ethylene diamine are added to the reaction pot, stir and heat to 120 ℃, react after 1 hour, then heat to 130 ℃, react for 1 hour. Ethylenediamine and water are distilled ,and after vacuum distillation, collect 180-240 ℃ (1.33-4 kPa) distillate, obtain 2- (1-naphthylmethyl) imidazoline. It is dissolved in a mixture of acetone and ethanol, and at 10-12℃ inlet hydrogen chloride gas to become into a salt, naphazoline hydrochloride crystals is generated . |
| Chemical Properties | white crystalline powder |
| Usage | adrenergic blocker |
| Usage | antihistamine |
| Naphazoline hydrochloride Preparation Products And Raw materials |
| Raw materials | 1-Methylimidazole-->Imidazolidine-->1-Naphthalene acetic acid |
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