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Paclitaxel 33069-62-4 C47H51NO14
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Henan Sunlake Enterprise Corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team.We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate.
Details:
| Product Name: | Paclitaxel |
| Synonyms: | N-BENZYL-BETA-PHENYLISOSERINE ESTER;PACLITAXEL, TAXUS BREVIFOLIA;PACLITAXEL, TAXUS SPECIES;PACLITAXOL;PACLITAXEL;TAXOL(TM);taxol a;TAXOL EQUIVALENT |
| CAS: | 33069-62-4 |
| MF: | C47H51NO14 |
| MW: | 853.91 |
| EINECS: | 205-285-7 |
| Product Categories: | Active Pharmaceutical Ingredients;Pharmaceutical material and intermeidates;Antineoplastics;Antineoplastic;APIs;Antitumors for Research and Experimental Use;Biochemistry;Natural Plant Extract;Intermediates & Fine Chemicals;Pharmaceuticals;Natural Anti-cancer Medical Materials and It's Derivatives;Antitumour;Signalling;Aromatics;Chiral Reagents;Heterocycles;Plant extract;API;Plant extracts;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;CLOBEX;Isolabel;antibiotic;Anti-cancer&immunity;Inhibitors |
| Mol File: | 33069-62-4.mol |
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| Paclitaxel Chemical Properties |
| mp | 213 °C (dec.)(lit.) |
| refractive index | -49 ° (C=1, MeOH) |
| storage temp. | 2-8°C |
| solubility | methanol: 50 mg/mL, clear, colorless |
| form | powder |
| color | white |
| Merck | 6982 |
| Stability: | Stable. Incompatible with strong oxidizing agents. Combustible. |
| CAS DataBase Reference | 33069-62-4(CAS DataBase Reference) |
| EPA Substance Registry System | Benzenepropanoic acid, .beta.-(benzoylamino)-.alpha.- hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S, 12aR,12bS)-6,12b-bis(acetyloxy)- 12-(benzoyloxy)-2a,3,4,4a, 5,6,9,10,11,12,12a,12b-dodecahydro- 4,11-dihydroxy-4a,8,13,13- tetramethyl-5-oxo-7,11-methano- 1H-cyclodeca[3,4]benz[1,2- b]oxet-9-yl ester, (.alpha.R,.beta.S)-(33069-62-4) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 37/38-41-42/43-62-68-40-48-20/21/22-68/20/21/22 |
| Safety Statements | 22-26-36/37/39-45 |
| RIDADR | 1544 |
| WGK Germany | 3 |
| RTECS | DA8340700 |
| F | 10-21 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Hazardous Substances Data | 33069-62-4(Hazardous Substances Data) |
| MSDS Information |
| Provider | Language |
|---|---|
| 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxete benzenepropanoic acid deriv. | English |
| SigmaAldrich | English |
| ACROS | English |
| Paclitaxel Usage And Synthesis |
| Outline | Paclitaxel is a monomer diterpenoid compound extracted from bark of the natural plant, taxus. It is a kind of complex secondary metabolites and is currently known as the only kind drug that can promote microtubule polymerization and stabilize polymerized microtubules. Isotopic tracing has showed that paclitaxel only binds to polymerized microtubules without reacting with the non-polymerized tubulin dimer. Cells will accumulate large amount of microtubules inside cells after exposure to paclitaxel with the accumulation of these microtubules being able to interfere with various kinds of cellular functions, in particular, being able to stop cell division in the mitosis phase, blocking the normal cell division. ThroughⅡ-Ⅲ clinical study, paclitaxel is mainly applied to the treatment of ovarian and breast cancer and also has certain efficacy in the treatment of lung cancer, colorectal cancer, melanoma, head and neck cancer, lymphoma and brain tumors. |
| Indications | It has good efficacy in the treatment of ovarian cancer and refractory ovarian cancer already being resistant to existing platinum and breast cancer. It also has good prospect on the treatment of prostate cancer, head and neck cancer, esophageal cancer, germ cell tumors, endometrial carcinoma, lymphoma, bladder cancer, upper gastrointestinal cancer, small cell and non-small cell lung cancer. |
| Small history |
In 1963, American chemist MC Wani and Monre E. Wall had isolated for the first time of the paclitaxel crude extract from the bark and wood of the pacific yew growing in the western forest of United States. During the screening experiments of taxus, Wani and Wall have discovered that crude extracts of paclitaxel are of great activity to the in vitro culture of mouse tumor cells and began to separate this active ingredient. Owing to the very low levels of the active ingredient in the plant, it was not until 1971 that they, through the cooperation with Professor Andre T. McPhail in Duke University, used x-ray analysis and successfully determined the chemical structure of the active ingredient - a kind of tetracylicditerpene and named it as paclitaxel (Paclitaxel). In 1971, it had been found of paclitaxel in taxus and found a unique anticancer mechanism. In 1992 the US government assigned the patent to Bristol-Myers Squibb and the paclitaxel emerged. In 1994, Paclitaxel ranks first in the global sales of world anti-cancer drugs. In 2000, the Paclitaxel sales had reached ten billion (after that, due to the supply limit of raw materials, the sales amount got no further rise). In 2002, the central government had forbidden the cutting of wild yew and had encouraged artificial cultivation. In 2004, the patent of Bristol-Myers Squibb has expired. More and more global pharmaceutical companies have been involved in Paclitaxel production. In 2004, Huayuan started to conduct the taxus project and build direct paclitaxel-specific extraction factory with the aims of becoming the largest yew base in China and Asia. In 2005, the Central government again issued a document for the national census of yew resources to encourage planting. In 2005, this project received investment from individual investors. The above information is edited |
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