Isoniazid

Product information

Isoniazid Basic information

Product Name:	Isoniazid
Synonyms:	4-PYRIDINECARBOHYDRAZIDE;4-PYRIDINECARBOXYLIC ACID HYDRAZIDE;AKOS BBS-00004103;HYCOZID;LABOTEST-BB LT00146690;INAH;ISONICOTINIC ACID HYDRAZIDE;ISONIAZIDE
CAS:	54-85-3
MF:	C6H7N3O
MW:	137.14
EINECS:	200-214-6
Product Categories:	AMIDE;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;NYDRAZID;Antituberculotic;API
Mol File:	54-85-3.mol

Isoniazid Chemical Properties

mp	171-173 °C(lit.)
Fp	>250°C
storage temp.	Refrigerator
Water Solubility	14 g/100 mL (25 ºC)
Sensitive	Air Sensitive
Merck	14,5186
BRN	119374
Stability:	Stability Stable, but may be air or light sensitive. Combustible. Incompatible with strong oxidizing agents, chloral, aldehydes, iodine, ferric salts, hypochlorites.
CAS DataBase Reference	54-85-3(CAS DataBase Reference)
NIST Chemistry Reference	Isoniazid(54-85-3)
EPA Substance Registry System	4-Pyridinecarboxylic acid, hydrazide(54-85-3)

Safety Information

Hazard Codes	Xn
Risk Statements	22-38-40-36/37/38
Safety Statements	37-36/37/39-26
RIDADR	2811
WGK Germany	3
RTECS	NS1751850
PackingGroup	III
HS Code	29333999
Hazardous Substances Data	54-85-3(Hazardous Substances Data)

MSDS Information

Provider	Language
INAH	English
SigmaAldrich	English
ACROS	English
ALFA	English

Isoniazid Usage And Synthesis

Chemical Properties	white crystalline powder
Usage	antibacterial, tuberculostatic
Usage	Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Sele ctively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antib acterial (tuberculostatic).
Usage	For the treatment of all forms of tuberculosis in which organisms are susceptible.
General Description	Odorless colorless or white crystals or white crystalline powder. Taste is slightly sweet at first and then bitter. pH (1% aqueous solution) 5.5-6.5. pH (5% aqueous solution) 6-8.
Air & Water Reactions	Sensitive to air and light. Absorbs insignificant amounts of moisture at 77°F at relative humidities up to approximately 90%. Water soluble. Dust can be explosive when suspended in air at specific concentrations.
Reactivity Profile	Isoniazid is incompatible with chloral, aldehydes, iodine, hypochlorites and ferric salts. Isoniazid is also incompatible with oxidizers. Isoniazid may react with sugars and ketones. Isoniazid can react as a weak acid or a weak base. Isoniazid can be decomposed by oxidative and reductive reactions.
Fire Hazard	Isoniazid is combustible.

Company information

 Henan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .

  Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs ,  Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East ,  Africa , South America and some other countries and areas.

    We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you  better with our high - quality products and professional team.

    We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.

    We  welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate.