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Keywords
923564-51-6 ABT 263 C47H55ClF3N5O6S3
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- Application:923564-51-6
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Details:
| ABT 263 Basic information |
| Product Name: | ABT 263 |
| Synonyms: | 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide;ABT 263;Benzamide, 4-(4-((2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl)methyl)-1-piperazinyl)-N-((4-(((1R)-3-(4-morpholinyl)-1-((phenylthio)methyl)propyl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)-;ABT-263,Navitoclax;Navitoclax;BenzaMide, 4-(4-((2-(4-chlorophenyl)-5,5-diMe;Navitoclax (ABT-263);(S)-4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-morpholino-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonyl)benzamide |
| CAS: | 923564-51-6 |
| MF: | C47H55ClF3N5O6S3 |
| MW: | 974.61 |
| EINECS: | |
| Product Categories: | Chiral Reagents;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Apis;Inhibitor |
| Mol File: | 923564-51-6.mol |
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| ABT 263 Chemical Properties |
| mp | 114-116°C |
| storage temp. | -20°C Freezer, Under Inert Atmosphere |
| Safety Information |
| ABT 263 Usage And Synthesis |
| Chemical Properties | Pale Yellow Solid |
| Usage | ABT-263 (Navitoclax) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ≤ 0.5 nM, ≤1 nM and ≤ 1 nM, respectively. |
| Usage | A novel inhibitor of antiapoptotic BCL-2 proteins; a new promising anticancer drug candidate. |
| ABT 263 Preparation Products And Raw materials |
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