Abiraterone Acetate for CRPC CAS:154229-18-2

Details:

Description                                           

English name: Abiraterone acetate

Synonyms:Abirateroneacetate;CB 7630;(3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-yl acetate

Specification: 98%

CAS NO.:154229-18-2

Appearance: White crystalline powder

Molecular weight: 391.55

Molecular formula:C26H33NO2

Introduction                                          

Abiraterone acetate, the active ingredient of ZYTIGA is the acetyl ester of abiraterone. Abiraterone is an inhibitor of CYP17 (17α-hydroxylase/C17,20-lyase). Each ZYTIGA tablet contains 250 mg of abiraterone acetate. Abiraterone acetate is designated chemically as (3β)-17-(3-pyridinyl)androsta-5,16-dien-3-yl acetate

Abiraterone acetate is a white to off-white, non-hygroscopic, crystalline powder. Its molecular formula is C26H33NO2and it has a molecular weight of 391.55. Abiraterone acetate is a lipophilic compound with an octanol-water partition coefficient of 5.12 (Log P) and is practically insoluble in water. The pKa of the aromatic nitrogen is 5.19.

Inactive ingredients in the tablets are colloidal silicon dioxide, croscarmellose sodium, lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone, and sodium lauryl sulfate.

Function                                               

Abiraterone is a drug used in castration-resistant prostate cancer. It is formulated as the prodrug abiraterone acetate. Abiraterone can be used as a prostate cancer drug treatment. Abiraterone is a inhibitor of CYP17. It can be used to treat CRPC.

COA                                                       

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25kgs packaging Fiber drum outside and plastic bag inside 1-25kgs packaging   aluminium bag outside and double plastic bag inside                                                                          

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