CasNo.2140-46-7,25-hYdroxycholesterol CAS NO.2140-46-7,(2140-46-7) Suppliers

1 Gram	Negotiable

Min.Order :1 Gram
Purity: 98%
Payment Terms : L/C,T/T,

Keywords

2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 25-Hydroxycholesterol (not deuterated) 2140-46-7

Quick Details

Appearance:white powder
Application:Eldecalcitol intermediate
PackAge:inquiry
ProductionCapacity:100|Metric Ton|Month
Storage:in stock/promptly
Transportation:fedex, dhl, other express,by sea or by air

Superiority:

Quick Details

CAS No.:: 2140-46-7

Other Names:: cholest-5-ene-3beta,25-diol

MF:: C27H46O2

EINECS No.:: 2140-46-7

Place of Origin:: Jiangxi, China (Mainland)

Type:: Pharmaceutical Intermediates, Syntheses Material Intermediates

Purity:: ≥99%

Brand Name:: YINGRUI

Model Number:: DAC170112

Application:: Pharmceutical/Chemical Industries

Appearance:: Solid

Test Method:: Based on EP 9.0/USP39/BP2015

Content:: 99.0% to 101.0%

Test method:: HPLC-ESI-MS

Water:: 0.5% Max.

Sulfated ash:: 0.1% Max.

Heavy metals:: 10ppm Max

Total Impurity:: 0.2% Max.

Total plate count:: ≤1000cfu/g

Yeast and Moulds:: ≤100cfu/g

E. Coli.:: Absent

Details:

Product Description

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Description

25-hydroxy Cholesterol is a side-chain substituted oxysterol derived from dietary cholesterol that inhibits the cleavage of sterol regulatory element binding proteins (SREBPs) to suppress endogenous cholesterol synthesis in various cell types. It has been implicated in a variety of metabolic events including cholesterol homeostasis and atherosclerosis as well as antitumor activities as it has been shown to induce apoptosis through down-regulation of Bcl-2 expression and activation of caspases. Immunomodulating capabilities have also been observed as the oxysterol can act as a LXR-RXR ligand coupling cholesterol synthesis to T cell proliferation, can reduce (EC50 ~ 65 nM) IgA production by B cells in response to IL-2, and can suppress differentiation of monocytes into macrophages.

Item	Standard		Test Results
Identification	A.H-NMR:Comply with the structure		Complies
	B.LC-MS:Comply with the structure		Complies
	C.The IR spectrum of sample should be identical with that of reference standard;		Complies
	D.HPLC-ESI-MS The retention time of the major peak in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay.		Complies
Crystallinity	meets the requirements.		Complies
Loss on drying	≤2.0%		0.19%
Heavy metals	≤10 ppm		<10ppm
Water	≤1.0%		0.1%
Sulphated ash	≤0.5%, determined on 1.0 g.		0.009%
Related substances	Unspecified impurities: for each impurity	≤0.10%	<0.10%
	Total Impurity	≤0.5%	0.18%
Purity	≥99.0%		99.7%
Assay	99.0%~101.0% (anhydrous substance).		99.8%
Microbiological Analysis
Total plate count	≤1000cfu/g		Complies
Yeast and Moulds	≤100cfu/g		Complies
E. Coli.	Absent		Negative
Salmonella	Absent		Negative
S.aureus	Absent		Negative
Storage	Preserve in well-closed, light-resistant and airtight containers.		Complies