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100 Kilogram	Negotiable

100 Kilogram

Negotiable

Min.Order :100 Kilogram
Purity: 99%
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

RARECHEM AH PB 0251 1405-20-5 C56H100N16O17S

Quick Details

Appearance:powder
Application:1405-20-5
PackAge:Depended
ProductionCapacity:300|Kilogram|Month
Storage:Refrigerator
Transportation:by air or by sea

Superiority:

Polymyxin B sulfate Basic information

Indications Dosage Drug Interactions Injection polymyxin B sulfate manufacturer Precautions Application

Product Name:	Polymyxin B sulfate
Synonyms:	POLYMYXIN B;POLYMYXIN-B 2,5-SULFATE;POLYMYXIN B SULFATE;POLYMYXIN B SULFATE, BACILLUS POLYMYXA;POLYMYXIN B SULFATE SALT;POLYMYXIN B SULPHATE;POLYMYXIN B (PMB);POLYMIXIN B SULFATE
CAS:	1405-20-5
MF:	C56H100N16O17S
MW:	1301.56
EINECS:	215-774-7
Product Categories:	Interferes with Cell Membrane Permeability (Ionophores)Spectrum of Activity;PeptidesCell Signaling and Neuroscience;Protein Kinase InhibitorsMore...Close...;Antibacterial;Antibiotics;Antibiotics A to;Antibiotics by Application;Antibiotics N-SAntibiotics;Antineoplastic and Immunosuppressive AntibioticsAntibiotics;Chemical Structure Class;Kinase/Phosphatase Biology;L - ZAntibiotics;Mechanism of Action;Peptides;beta-Lactam StructureAntibiotics;PeptidesAlphabetic;POLB - POLYMore...Close...;Chemical Structure;P;AntibioticsAntibiotics;Cell Culture;PeptidesMore...Close...;Reagents and Supplements;Intermediates & Fine Chemicals;Pharmaceuticals;AEROSPORIN;antibiotic;Inhibitors
Mol File:	1405-20-5.mol

Polymyxin B sulfate Chemical Properties

mp	217-220°C (dec.)
storage temp.	2-8°C
solubility	H₂O: 50 mg/mL
form	powder
Merck	13,7656
CAS DataBase Reference	1405-20-5(CAS DataBase Reference)
EPA Substance Registry System	Polymyxin B, sulfate(1405-20-5)

Safety Information

Hazard Codes	Xn
Risk Statements	22
Safety Statements	22-24/25
RIDADR	3249
WGK Germany	3
RTECS	TR1150000
F	3-8-10
HazardClass	6.1(b)
PackingGroup	III

MSDS Information

Provider	Language
SigmaAldrich	English

Polymyxin B sulfate Usage And Synthesis

Indications	Polymyxin B sulfate is similar with polymyxin E, and has either bacteriostatic or bactericidal effect on various kinds of gram-negative bacteria, such as Escherichia coli, Pseudomonas aeruginosa, Escherichia coli deputy, Klebsiella pneumoniae, acidophilus, Bordetella pertussis and Shigella dysentery. It is mainly applied to the treatment of infection in wounds, the urinary tract, eyes, ears, and bronchus caused by Pseudomonas aeruginosa and other kinds of pseudomonas. It can also be applied for treating sepsis, peritonitis, and severe infection caused by aminoglycoside-resistant, third generation cephalosporins-resistant bacteria and Pseudomonas aeruginosa or other sensitive strains, such as bacteremia, endocarditis, pneumonia, and burn infection.
Dosage	1. Intravenous injection: Adults and children with normal renal function: 1.5 to 2.5 mg per kilogram of body weight per day (for per kg body weight, generally apply not more than 2.5 mg), divide into 2 times with 1 time every 12 hours of infusion. Dilute every 50mg of the product with 500 mL of 5% glucose solution and further add drop wise. Babies with normal renal function can tolerate a amount of 4 mg/day per kilogram of body weight. 2. Intramuscular injection: Adults and children: apply 2.5 to 3 mg per kilogram of body weight; apply in divided doses with applying 1 time every 4 to 6 hours. For baby, the dosage can be 4 mg per day per kilogram of body weight. For new born children, we can apply to 4.5 mg per time per kilogram of body weight. 3. intrathecal injection (for Pseudomonas aeruginosa meningitis): Each mL of drug solution prepared by the sodium chloride injection contains 5mg. Adults and children with over 2 years of age, apply 5 mg daily; after application of 3 to 4 days, change one time every other day, and continue for at least 2 weeks until the result of cerebrospinal fluid culture becomes negative and the sugar inspection becomes normal. For children less than 2 years of age, apply 2mg 1 time per day for continuous 3 to 4 days (or 2.5mg per every other day); after that, apply 2.5mg every other day, until the test becomes normal. 4. The ophthalmic solution concentration: 1 ~ 2.5mg per milliliter.
Drug Interactions	We should avoid apply it in combination with drugs causing significant damage to the kidneys, skeletal muscle relaxants, aminoglycoside antibiotics, and anesthetic drugs with significant effect of muscle relaxation (such as enflurane). Also we should avoid simultaneous intravenous administration of quinine, and magnesium. Combining polymyxin B sulfate with sulfa drugs, rifampicin, and semi-synthetic penicillin has a better efficacy than single application in treating severe infections resistant Gram-negative bacteria. The above information is edited by the chemicalbook of Dai Xiongfeng.
Injection polymyxin B sulfate manufacturer	Shanghai “Xin Xianfeng” Pharmaceutical Co., Ltd. Zhunzi H31022973 Shanghai No. 1 Biochemical Pharmaceutical Co., Ltd. Zhunzi H31022631
Precautions	1. Pregnant and lactating women, children, patients with severe kidneys damage and severe kidney dysfunction should either take with caution or reduce the administrated amount. 2. this product has relative large toxicity and a poor efficacy in treating deep tissue infection. It is also not the primary choice of drug for treating any kinds of infection. 3. intravenous injection may lead to respiratory depression and thus should generally not used. Half of the amount in daily dose should subject to intravenous drip, and can’t subject to disposable rapid bolus avoid extensive neuromuscular blockade. 4. it shouldn’t be used in combination with drugs with other renal toxicity or neuromuscular blocking effects to avoid accidents.
Application	Biochemical studies. Polymyxin B is a kind of anti-Gram-negative poly-peptide antibiotics which can alter membrane structure allowing small molecules leakage and inhibit the growth of Gram-negative bacteria. It has bactericidal effect on Escherichia coli through binding to the lipid A portion of bacterial lipopolysaccharide. Mechanism of action: bind and interfere with the permeability o the cellular membrane. Anti-bacteria spectrum: gram negative bacteria.
Chemical Properties	White Solid
Usage	antibacterial
Usage	Antibiotic with bactericidal action on E. coli. Binds to the lipid A portion of bacterial lipopolysaccharides. Induces pore formation in the membranes of cortex cells from excised sorghum roots. Mixtu re of Polymyxin B1 and B2 sulfate. Biological potency (dry basis): >6000U/mg.

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