CasNo.58970-76-6,58970-76-6 C16H24N2O4,(58970-76-6) Suppliers

100 Kilogram	Negotiable

Min.Order :100 Kilogram
Purity: 99%
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

RARECHEM AH PB 0251 58970-76-6 C16H24N2O4

Quick Details

Appearance:powder
Application:58970-76-6
PackAge:Depended
ProductionCapacity:300|Kilogram|Month
Storage:Refrigerator
Transportation:by air or by sea

Superiority:

Ubenimex Basic information

Product Name:	Ubenimex
Synonyms:	3-(r)-amino-2-(s)-hydroxy-4-phenylbutanoyl-(s)-leucine;n-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-,(s-(r,s))-l-leucin;nk421;UBENIMEX;N-[(2S,3R)-3-AMINO-2-HYDROXY-1-OXO-4-PHENYLBUTYL]-L-LEUCINE;N-((2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL)-L-LEUCINE;[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRYL]-L-LEUCINE;[(2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-LEU
CAS:	58970-76-6
MF:	C16H24N2O4
MW:	308.37
EINECS:	261-529-2
Product Categories:	Active Pharmaceutical Ingredients;Ubenimex;Pepetides;ProteaseInhibitors;peptides;Bestatin
Mol File:	58970-76-6.mol

Ubenimex Chemical Properties

mp	245 °C (dec.)(lit.)
storage temp.	2-8°C
Merck	13,9910
CAS DataBase Reference	58970-76-6(CAS DataBase Reference)

Safety Information

Safety Statements	22-24/25
WGK Germany	3
RTECS	OH2915000

MSDS Information

Provider	Language
Ubenimex	English
ACROS	English
SigmaAldrich	English

Ubenimex Usage And Synthesis

Chemical Properties	white powder
Usage	Ubenimex is a competitive aminopeptidase B inhibitor with an IC50 of 100 mg/ml for K562 cells. Proliferation of all the cell lines except KG1 was inhibited by bestatin. P39/TSU, HL60 and U937 were highly sensitive, with 50% growth inhibitory concentration
Usage	Bestatin is "pseudo"-dipeptide isolated from Strepotmyces olivreticuli in 1976. Bestatin is a potent aminopeptidase B inhibitor with no carboxypeptidase activity. Bestatin acts as an immunomodulator by activating macrophages and T lymphocytes. Bestatin also exhibits good antitumour activity and is has been investigated in clinical trials.
Usage	Bestatin is "pseudo"-dipeptide isolated from Streptomyces olivreticuli in 1976. Bestatin is a potent aminopeptidase B inhibitor with no carboxypeptidase activity. Bestatin acts as an immunomodulator by activating macrophages and T lymphocytes. Bestatin also exhibits antitumor activity and has been investigated in clinical trials.
Biological Activity	Aminopeptidase inhibitor (K i = 0.001-90 mM); inhibits enkephalin metabolism and leukotriene A 4 hydrolase. Inhibits tumor cell proliferation.

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