198275-79-5 C15H10O7

Min.Order / FOB Price:Get Latest Price

100 Kilogram	Negotiable

100 Kilogram

Negotiable

Min.Order :100 Kilogram
Purity: 99%
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

RARECHEM AH PB 0251 1692-25-7 C15H10O7

Quick Details

Appearance:powder
Application:319-89-1
PackAge:Depended
ProductionCapacity:300|Kilogram|Month
Storage:Refrigerator
Transportation:by air or by sea

Superiority:

Quercetin Basic information

Expectorants Pharmacological effects Chemical Properties Application Production method

Product Name:	Quercetin
Synonyms:	2-(3,4-DIHYDROXYPHENYL)-3,5,7-TRIHYDROXY-4H-1-BENZOPYRAN-4-ONE;3,3',4',5,6-PENTA-HYDROXY-FLAVONE;3,3',4',5,7-PENTAHYDROXYFLAVONE;AKOS NCG1-0081;MELETIN;FLAVIN MELETIN;LABOTEST-BB LT00455149;CI NO 75670
CAS:	117-39-5
MF:	C15H10O7
MW:	302.24
EINECS:	204-187-1
Product Categories:	Pharmaceutical Raw Materials;Miscellaneous Natural Products;Functional Products;Natural Plant Extract;Caspases/Apoptosis;reference substance;Plant extracts;Herb extract;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Inhibitors
Mol File:	117-39-5.mol

Quercetin Chemical Properties

mp	314-317°C
storage temp.	Store at 0-5°C
Water Solubility	<0.1 g/100 mL at 21 ºC
Merck	13,8122
CAS DataBase Reference	117-39-5(CAS DataBase Reference)
EPA Substance Registry System	4H-1-Benzopyran- 4-one, 2-(3,4-dihydroxyphenyl)-3, 5,7-trihydroxy-(117-39-5)

Safety Information

Hazard Codes	T,Xi
Risk Statements	25-36/37/38
Safety Statements	45-36-26
RIDADR	2811
RTECS	LK8750000
HazardClass	6.1(b)
PackingGroup	III
Hazardous Substances Data	117-39-5(Hazardous Substances Data)

MSDS Information

Provider	Language
3,3',4',5,7-Pentahydroxyflavone	English

Quercetin Usage And Synthesis

Expectorants	Quercetin is commonly used as a expectorant drug in clinical medicine in China. This product has various kinds of pharmacological functions such as having a good expectorant, cough effect, also having certain anti-asthma effect, and having further effects of lowering blood pressure, enhancing capillary resistance, reducing capillary fragility, reducing blood fat, expansion of coronary artery, increasing coronary blood flow. Clinically, quercetin is mainly used for treating clinical bronchitis and phlegmatic inflammation. It also has adjuvant therapy effect on coronary artery disease and high blood pressure. FDA may have some kinds of adverse reactions such as dry mouth, dizziness, and burning sensation in stomach area which may disappear after treatment. Quercetin is widely distributed in angiosperms such as Threevein Astere, Golden Saxifrage, berchemia lineata, gold, rhododendron dauricum, seguin loquat, purple rhododendron, Rhododendron micranthum, Japanese Ardisia Herb and Apocynum. It is a kind of aglycon which mainly combines with carbohydrate to be in the form of glycosides, such as quercetin, rutin, hyperoside.
Pharmacological effects	Quercetin can significantly inhibit the effect of cancer-promoting agent, inhibiting the growth of malignant cells in vitro, inhibiting the DNA, RNA, and protein synthesis of Ehrlich ascites tumor cells. Quercetin has effects of inhibiting the platelet aggregation and the release effect of serotonin (5-HT) as well as inhibiting the platelet aggregation process which is induced by ADP, thrombin and platelet-activating factor (PAF) in which having the strongest inhibition effect on PAF. Moreover, it can also inhibit thrombin-induced the release of platelet 3H-5-HT of rabbit. (1) Intravenously adding 0.5mmol/L quercetin (10ml/kg) drop wise can significantly shorten the duration of arrhythmia in mice of myocardial ischemia and reperfusion, reduce the incidence of ventricular fibrillation, and reduce the content of MDA as well as the activity of xanthine oxidase inside the ischemic myocardial tissue while having significantly protective effect on SOD. This may be related to the inhibition of the formation process of myocardial oxygen free radical and protection of SOD or directly scavenging of radical free oxygen in myocardial tissue. (2) Having in vitro assay with quercetin and rutin being together can disperse the platelet and thrombus adhered to the rabbit aorta endothelium with an EC50 of 80 and 500nmol/L, respectivly. In vitro assay of a concentration of quercetin at 50 ~ 500μmol/L has shown that it can improve cAMP level inside human platelet, enhance the PGI2-induced improvement of cAMP level of human platelet and inhibit the ADP-induced platelet aggregation. Quercetin at a concentration ranged from 2 ~ 50μmol/L has a concentration-dependent enhancement effect. Quercetin, at a concentration of 300 μmol/L in vitro can not only almost completely inhibit the process of platelet aggregation induced by platelet-activating factor (PAF), but also inhibit thrombin and ADP-induced platelet aggregation as well as inhibit the release of rabbit platelet 3H-5HT induced by thrombin; A concentration of 30 μmol/L can significantly reduce the liquidity of platelet membrane. (3) Quercetin, at a concentration at 4×10-5~1×10-1g/ml, has a inhibitory effect on the release of histamine and SRS-A in the lung of ovalbumin-sensitized guinea pig lung; A concentration of 1 × 10-5g/ml also has inhibitory effect on the for SRS-A induced ileum contraction of guinea pig. Quercetin, at a concentration of 5 ~ 50μmol/L, has a concentration-dependent inhibitory effect on the process of histamine release of human basophilic leucocyte. Its inhibitory effect on the ileum contraction of ovalbumin sensitized guinea pig is also concentration-dependent with an IC50 of 10μmol/L. A concentration in the range of 5×10-6 ~ 5×10-5mol L can inhibit the proliferation of cytotoxic T lymphocyte (CTL) as well as inhibit ConA-induced DNA synthesis. The above information is edited by the Chemicalbook of Dai Xiongfeng.
Chemical Properties	It is yellow needle-like crystalline powder. It has good thermal stability with the decomposition temperature being 314 °C. It can improve the light-tolerance property of food pigment for preventing the change of the flavor of food. Its color will change in case of metal ion. It is slightly soluble in water, soluble in an alkaline aqueous solution. Quercetin and its derivatives is a kind of flavonoid compound which are widely present in a variety of vegetables and fruits such as onions, sea buckthorn, hawthorn, locust, tea. It has effects of anti-free radical, anti-oxidation, anti-bacterial, anti-viral as well as anti-allergic. For application in lard, its various antioxidant indicators are similar with that of BHA or PG. Because of the double bond between the 2,3 position as well as the two hydroxyl groups in 3 ', 4' , it has application of being used as a metal chelate or being the receptor of the free groups produced during the oxidation process of grease. In this case, it can be used as the antioxidants of ascorbic acid or grease. It also has a diuretic effect.
Application	1. It can be used as a kind of antioxidant which is mainly used for oil, drinks, cold drinks, meat processing products. 2. It has good effects of expectorant, anti-cough, anti-asthma and can be used for treating chronic bronchitis as well as for adjuvant therapy of coronary heart disease and high blood pressure. 3. It can also be used as analytical standards
Production method	1. Crash the bark of trees in Fagaceae Quercus (Quercus) into powder, wash with hot brine, extract with dilute ammonia before neutralization with dilute sulfuric acid. Boil the filtrate and separate crystals. 2. It can be obtained by extracting Liliaceae onion (Alliumcepa) with 95% ethanol; it can also be produced from rutin (rutin) extract, quercetin, isoquercitrin, fennel glycosides, hyperoside, quercimeritrin, bloom glycosides through rutin degrading enzyme or hydrolysis with acidic aqueous solution.
Chemical Properties	Yellow to green yellow crystalline powde
General Description	Yellow needles or yellow powder. Converts to anhydrous form at 203-207°F. Alcoholic solutions taste very bitter.
Air & Water Reactions	Sensitive to exposure to air and light. Insoluble in water.
Reactivity Profile	3,3',4',5,7-Pentahydroxyflavone is a strong antioxidant and a metal chelator. Promotes the formation of nitrosamines .
Health Hazard	ACUTE/CHRONIC HAZARDS: When heated to decomposition 3,3',4',5,7-Pentahydroxyflavone emits acrid smoke and irritating fumes.
Fire Hazard	Flash point data for 3,3',4',5,7-Pentahydroxyflavone are not available; however, 3,3',4',5,7-Pentahydroxyflavone is probably combustible.
Biological Activity	Anti-tumor agent; induces apoptosis and inhibits synthesis of heat shock proteins. Inhibits many enzyme systems including tyrosine protein kinase, phospholipase A 2 , phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C. Can also activate Ca 2+ and K + channels and behaves as an agonist at estrogen (GPR30) receptors.

Service we provide:

1. Mixed container, we can mix different items in one container.

2. Quality control, before shipment, free sample for test. after shipment, keep sample for 3 years

3. Prompt shipment with professional documents

4. Packing as your request, with photo before shipment

Details:

Exhibition in shanghai

We have clients throughout the world：

Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet your desire.

Our Laboratoy

We have our own independent lab test center：

This makes sure that our technology support is reliable and authoritative.All of self-owned fine chemicals are manufactured strictly in accordance with international standard.,and also has scientific cooperation with local colleges and institutes.