RARECHEM AH PB 0251 439081-18-2 C24H25ClFN5O3
BIBW 2992 Basic information |
Product Name: | BIBW 2992 |
Synonyms: | BIBW 2992;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide;Tovok;Tovok, BIBW 2992;BIBW2992 Afatinib;Afatinib (BIBW 2992);ToMtovok;(S,E)-N-(4-(3-chloro-4-fluorophenylaMino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(diMethylaMino)but-2-enaMide |
CAS: | 439081-18-2 |
MF: | C24H25ClFN5O3 |
MW: | 485.944 |
EINECS: | |
Product Categories: | API;Inhibitors |
Mol File: | 439081-18-2.mol |
BIBW 2992 Chemical Properties |
density | 1.380 |
Safety Information |
BIBW 2992 Usage And Synthesis |
Usage | BIBW2992 (Afatinib, Tomtovok, Tovok) irreversibly inhibits EGFR/HER2 including EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2 with IC50 of 0.5 nM, 0.4 nM, 10 nM and 14 nM, respectively. |
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