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RARECHEM AH PB 0251 10238-21-8 C23H28ClN3O5S
5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]-amino]sulfonyl]phenyl]-ethyl]-2-methoxybenzamide Basic information |
Product Name: | 5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]-amino]sulfonyl]phenyl]-ethyl]-2-methoxybenzamide |
Synonyms: | LABOTEST-BB LT00244861;GLYBENCLAMIDE;GLYBENZCYCLAMIDE;GLYBURIDE;GIBENCLAMIDE;GLIBENCLAMIDE;5-CHLORO-N-[4-(CYCLOHEXYLUREIDOSULFONYL)PHENETHYL]-2-METHOXYBENZAMIDE;5-CHLORO-N-[2-[4-[[[(CYCLOHEXYLAMINO)CARBONYL]AMINO]-SULFONYL]PHENYL]ETHYL]-2-METHOXYBENZAMIDE |
CAS: | 10238-21-8 |
MF: | C23H28ClN3O5S |
MW: | 494 |
EINECS: | 233-570-6 |
Product Categories: | Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Organics;Amino Acids & Derivatis;Isotope Labeled Compounds;API's;Potassium channel;Ion Channels;Isotope Labelled Compounds;API;GLYNASE;Diabetes Research |
Mol File: | 10238-21-8.mol |
5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]-amino]sulfonyl]phenyl]-ethyl]-2-methoxybenzamide Chemical Properties |
mp | 173-175°C |
storage temp. | 2-8°C |
Merck | 13,4491 |
CAS DataBase Reference | 10238-21-8(CAS DataBase Reference) |
NIST Chemistry Reference | Glyburide(10238-21-8) |
Safety Information |
Hazard Codes | Xn |
Risk Statements | 20/21/22 |
Safety Statements | 22-36/37/39-36 |
RTECS | YS4725200 |
MSDS Information |
Provider | Language |
---|---|
5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]-amino]sulfonyl]phenyl]-ethyl]-2-methoxybenzamide | English |
ALFA | English |
5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]-amino]sulfonyl]phenyl]-ethyl]-2-methoxybenzamide Usage And Synthesis |
Chemical Properties | White Crystalline Powder |
Usage | antihyperglycemic |
Usage | Glyburide is a second generation sulfonylurea with hypoglycemic activity. Glyburide is an antidiabetic. |
Biological Activity | ATP-dependent K + channel (K ATP ) and CFTR Cl - channel blocker. Inhibits K ATP currents in the pancreas, causing an increase in intracellular Ca 2+ and insulin secretion. Inhibits recombinant CFTR Cl- channels with an IC 50 of 20 μ M. |
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