Offer 66722-44-9 Bisoprololwith stable stock

Offer 66722-44-9 Bisoprololwith stable stock

Min.Order / FOB Price:Get Latest Price

1 Kilogram	FOB Price: USD 1.0000

1 Kilogram

FOB Price: USD 1.0000

Min.Order :1 Kilogram
Purity: 98% purity
Payment Terms : L/C,T/T,Other

Keywords

Offer CAS.NO: 66722-44-9 Bisoprolol from own lab Supply 66722-44-9 with best price Sale 66722-44-9 C18H31NO4 Bisoprolol

Quick Details

Appearance:white crystalline powder
Application:66722-44-9
PackAge:1g;5g;10g;25g;50g;100g;500g;1KG;5KG or as customers request
ProductionCapacity:50|Kilogram|Month
Storage:Room temperature with sealed well
Transportation:BY SEA /BY AIR /BY COURIER

Superiority:

1. ISO 9001 approved, GMP producing standard,Proffesional QA system, our quality is guaranteed.

2. Facotory direct sale, most comptive price ensured;

3. Audited Supplier on lookchem, No trick, No Scam!

4. Enough stock can make sure safe delivery.

5. Complete before and after sale service, welcome your questions and glad to help.

66722-44-9

Details:

Bisoprolol Basic information

Cardiovascular drugs Application Category Toxicity grading Acute toxicity Flammability hazard characteristics Storage Characteristics Extinguishing agent

Product Name:	Bisoprolol
Synonyms:	BISOPROLOL;2-PROPANOL, 1-[4-[[2-(1-METHYLETHOXY)ETHOXY]METHYL]PHENOXY]-3-[(1-METHYLETHYL)AMINO]-;Bisoprolo;Bisoprolol(Hemifumalate);Bisoprolol base;1-(p-2-Isopropoxyethoxymethylphenoxy)-3-isopropylaminopropan-2-ol;Racemic Bisoprolol;1-[4-[2-(1-Methylethoxy)ethoxymethyl]phenoxy]-3-(1-methylethylamino)propan-2-ol
CAS:	66722-44-9
MF:	C18H31NO4
MW:	325.44
EINECS:
Product Categories:	Intermediates & Fine Chemicals;Isotope Labeled Compounds;Pharmaceuticals;Isotope Labelled Compounds;API
Mol File:	66722-44-9.mol

Bisoprolol Chemical Properties

storage temp.	-20°C Freezer, Under Inert Atmosphere
CAS DataBase Reference	66722-44-9(CAS DataBase Reference)
NIST Chemistry Reference	Bisoprolol(66722-44-9)

Safety Information

Hazard Codes	Xn
Risk Statements	22
HazardClass	IRRITANT

MSDS Information

Bisoprolol Usage And Synthesis

Cardiovascular drugs	Bisoprolol is successfully developed by the German Merck in 1978, in the world ,it is already the drug of choice on clinicalcommonly used to treat hypertension, angina, arrhythmias and heart failure and other cardiovascular diseases, the product is highly selective β1-adrenergic receptor blocker,it has hydrophilic and lipophilic properties,it has no intrinsic sympathomimetic activity and membrane stability, and its negative inotropic effect is weaker.It has two β receptor binding sites with ultra-high affinity and high affinity ,its drug action is extremely powerful,it is 7 to 10 times stronger than atenolol and metoprolol . It has highly β1 receptor selectivity, selective research about model complex β1 / β2 finds out that: propranolol is 1/3,atenolol is 20/1 , bisoprolol is 60/1. Another study compares the β1 / β2 selectivity of metoprolol and bisoprolol, the results show that the former is 74/1,the latter is 119/1. Like other β-blockers, bisoprolol by blocking heartβ1 receptors, and inhibiting the renin - angiotensin system, plays a role in the treatment of hypertension, angina, arrhythmia. Recent studies indicate that substance P has effect on dilating the blood vessels to reduce the role of peripheral resistance, content of substance P in patients with hypertension decreases significantly,there is a significant rebound of substance P while there is a decrease in blood pressure after the treatment of bisoprolol, which may be one of the possible mechanisms of antihypertension . Another study shows that bisoprolol can not only decrease the blood pressure, but can also improve diastolic function; it has no adverse effects on blood sugar, blood lipids , conclusion in diabetics is also like this . It is mainly used to treat supraventricular tachycardia, atrial fibrillation, ventricular premature contraction, coronary heart disease, angina, mild to moderate hypertension, it is also used in heart failure caused by dilated cardiomyopathy and ischemic heart disease. Oral F is up to 88%. Tmax is 1.5 ~ 3 h. PPB is 30%. Plasma clearance T1 / 2 is 10 ~ 12 h. The one dose effect can be maintained for 24 h. Because its hydrophilic character is equal to lipophilic character, its adverse reactions on central nervous system are lighter than metoprolol with lipophilic character,and its adverse reactions on renal function is smaller compared withatenolol with hydrophilic character . Bisoprolol have two equal clearance ways ,half of it is metabolized to the non-active substances in the liver , the other half is excreted in the form of the prototype by the kidneys. [Note and taboos]it is similar to atenolol. The above information is edited by the chemicalbook of Tian Ye.
Application	It is used for the treatment of cardiovascular and cerebrovascular diseases.
Category	Toxic Substances
Toxicity grading	Middle toxic
Acute toxicity	Intravenous - Mouse LD50: 164 mg / kg.
Flammability hazard characteristics	Combustible; combustion produces toxic nitrogen oxide gases.
Storage Characteristics	Ventilated, low-temperature ,dry storeroom.
Extinguishing agent	Water, dry powder, foam, sand.
Chemical Properties	Yellow Oil
Usage	A selective a-adrenergic blocker. Used as an antihypertensive
Usage	A selective β-adrenergic blocker. Used as an antihypertensive.

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