ketoconazole

product Name

ketoconazole

Synonyms

cis-1-acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1h-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine; 1-[4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethanone; 1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethanone; 1-[4-(4-{[(2S,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethanone; 1-acetyl-4-(4-{[(2R)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine

Molecular Formula

C₂₆H₂₈Cl₂N₄O₄

Molecular Weight

531.4309

InChI

InChI=1/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23 ,26-/m0/s1

CAS Registry Number

65277-42-1;79156-75-5

EINECS

265-667-4

Molecular Structure

Density

1.38g/cm³

Melting point

146℃

Boiling point

753.4°C at 760 mmHg

Refractive index

1.642

Flash point

409.4°C

Vapour Pressure

1.39E-22mmHg at 25°C

Hazard Symbols

T:Toxic;

Risk Codes

R25;

Safety Description

S36;
S45;

Appearance

White or almost white powder

Solubility

Practically insoluble in water, freely soluble in methylene chloride, soluble in methanol, sparingly soluble in ethanol(96 per cent)

Identification

A: Melting point

148℃ ~ 152 ℃

B: IR

Complies with CRS

C:Thin-layer chromatography

Correspond with the working standard

D:

Gives reaction of chlorides

Appearance of solution S

Clear and not more intensely coloured than reference solution BY₄

Optical rotation

-0.10° to +0.10°

Related substance

Total impurities

Not more than 0.5%

Disregard limit

Not more than 0.05%

Heavy metals

Maximum 20ppm

Loss on drying

Maximum 0.5%

Sulphated ash

Maximum 0.1%

Content

99.0% ~ 101.0%

Storage

Protected from light