XL518

XL518
XL518
XL518

XL518

Min.Order / FOB Price:Get Latest Price

100 Kilogram

Negotiable

  • Min.Order :100 Kilogram
  • Purity: 99%
  • Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

XL518 934660-93-2 C21H21F3IN3O2

Quick Details

  • Appearance:powder
  • Application:934660-93-2
  • PackAge:Depended
  • ProductionCapacity:300|Kilogram|Month
  • Storage:Store in dry, dark and ventilated place
  • Transportation:by air or by sea

Superiority:

XL518 Basic information
Product Name: XL518
Synonyms: XL518;GDC-0973;RG7420;[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)aMino]phenyl][3-hydroxy-3-[(2S)-2-piperidinyl]-1-azetidinyl]Methanone;GDC-0973(XL-518);(S)-(3,4-difluoro-2-(2-fluoro-4-iodophenylaMino)phenyl)(3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl)Methanone;XL518 ,GDC-0973;CobiMetinib
CAS: 934660-93-2
MF: C21H21F3IN3O2
MW: 531.3100196
EINECS:  
Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Protein Kinase Inhibitors and Activators;API
Mol File: 934660-93-2.mol
XL518 Structure
 
XL518 Chemical Properties
density  1.706
 
Safety Information
MSDS Information
 
 
XL518 Usage And Synthesis
Usage A potent, selective, orally bioavailable inhibitor of MEK1, a component of the RAS/RAF/MEK/ERK pathway. It inhibits proliferation and stimulates apoptosis in a variety of human tumor cell lines. In preclinical xenograft models, oral administration of XL518 results in sustained inhibition of pERK in tumor tissue, but not brain tissue, leading to tumor growth inhibition and regression at well tolerated doses.

 

Details:

  • Exhibition in shanghai

 

 

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