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100 Kilogram	Negotiable

100 Kilogram

Negotiable

Min.Order :100 Kilogram
Purity: 99%
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Niclosamide 50-65-7 C12H15NO2

Quick Details

Appearance:powder
Application:50-65-7
PackAge:Depended
ProductionCapacity:300|Kilogram|Month
Storage:Refrigerator
Transportation:by air or by sea

Superiority:

Niclosamide Basic information

Anti-parasitic disease drug Chemical Properties Application Production Method Category Toxicity grading Acute toxicity Flammability and hazard characteristics Storage Characteristics Extinguishing agent

Product Name:	Niclosamide
Synonyms:	2’,5-dichlor-4’-nitro-salizylsaeureanilid;2’,5-dichlor-4’-nitro-salizylsaeureanilid[german];2’,5-dichloro-4’-nitro-salicylanilid;5-chloro-n-(2-chloro-4-nitrophenyl)-2-hydroxy-benzamid;5-chlorosalicyloyl-(o-chloro-p-nitranilide);b2353;bay2353;bayer2353
CAS:	50-65-7
MF:	C13H8Cl2N2O4
MW:	327.12
EINECS:	200-056-8
Product Categories:	Veterinaries;API's;Pharmaceutical intermediate;PERMAX;Other APIs;intermediates
Mol File:	50-65-7.mol

Niclosamide Chemical Properties

storage temp.	0-6°C
CAS DataBase Reference	50-65-7(CAS DataBase Reference)
EPA Substance Registry System	Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)- 2-hydroxy-(50-65-7)

Safety Information

RIDADR	UN 3077 9/PG 3
WGK Germany	2
RTECS	VN8400000
Hazardous Substances Data	50-65-7(Hazardous Substances Data)

MSDS Information

Provider	Language
Niclosamide	English
SigmaAldrich	English

Niclosamide Usage And Synthesis

Anti-parasitic disease drug	Niclosamide belongs to the taeniafuge drugs of the anti-parasitic disease drugs , it is less toxic, it has a high efficacy on a variety of tapeworm, tapeworm mechanism is hampering tapeworm Krebs cycle, so that lactic acid is accumulated which can cause the death of the parasites, it is drug of choice in livestock and poultry, pet tapeworm prevention . Oral absorption from the gastrointestinal tract is very little, so it can maintain a high concentration in the intestine, it has a strong insecticidal action against the pork tapeworm, and beef tapeworm short Hymenolepis . Low concentrations of the drug can promote parasite uptake, while high concentrations of the drug can inhibit mitochondrial oxidative phosphorylation of the parasite, and hinder the absorption of glucose uptake,and result in tapeworm head and proximal segments death, and elimination with the feces from the intestinal wall . Mainly it is used for tapeworm infection, but it is also used as molluscidal drugs which can kill snails and snail eggs, cercariae and miracidia. It has high rate of snail eradication , slow effect, long residual effect, it is used for the prevention of schistosomiasis, the temperature above 20 ℃ is better. In addition ,the product is friendly to human, animal and plant,it is very toxic to fish, so use in the fish ponds is forbidden . 1960 Germany reported a synthetic chemical repellent - Niclosamide whose code is Bayer 73 the drug is pale yellow powder, odorless, tasteless. Insoluble in water, slightly soluble in alcohol, ether and chloroform,it can be dissolved in hot ethanol, cyclohexanone and an aqueous solution of sodium hydroxide, the compound is stable.Niclosamide have a better effect on beef tapeworm, pork tapeworm, H. nana and Diphyllobothrium tapeworm, . Few drug absorption occurs in the gastrointestinal tract, when the drug is exposed with parasites, parasites die soon. Therefore, when the medication, the tablets should be chewed, so drugs can make full contact with tapeworm parasites, and a lot of water immediately should be avoided, in order to maintain a high concentration of upper small intestine where lies the parasitic tapeworm . The drug can kill adults tapeworm rather than eggs tapeworm , in order to prevent vomiting, which make the eggs reflux into stomach , and cause the risk of cysticercosis occurring, anti-emetics should be added before the medication . 2 hours after administration, it should be served magnesium sulfate for catharsis, to get rid of the parasite and the cleaved head section and debris. The drug has low toxicity, rat oral LD50 of 5g / kg. This product can also be made with amino ethanol to serve as soluble snail drugs under the trade name niclosamide (bayluscide),in the country, Niclosamide and alkali waste pulp can be made for soluble pastes, called schistosomiasis - 67. These can be used to kill the snail which is the intermediate host of Schistosoma japonicum. Regardless of spraying or soaking ,the amount of snail, is 1g / m2. Pulp paste for live use (ie schistosomiasis-67), accounts for 50% of Niclosamide . Oral adverse reactions are mild, except for gastrointestinal reactions, occasional dizziness, chest tightness, fever and other discomfort occur. There is no liver, kidney, blood system injury. The above information is edited by the chemicalbook of Tian Ye.
Chemical Properties	Yellow-white crystalline powder, odorless, tasteless. Melting point 225-230 ℃. Insoluble in water, soluble in hot ethanol, chloroform, cyclohexanone, diethyl ether and sodium hydroxide solution.
Application	It is used to control snails, etc. Molluscidal medicine, molluscicides,which are applied to kill the water snails, freshwater oncomelania,it has effect on snails bodies and snail eggs . Alsoit can be used as taeniafuge drugs for repelling beef tapeworm and pork tapeworm.
Production Method	The same amount of 2-chloro-4-nitroaniline and 5-chloro-salicylate are dissolved in xylene (or chlorobenzene), it is heated to boiling, then it is slowly added phosphorus trichloride (or phosphorus oxychloride), after that the reflux is continued for 3h. After cooling, the crystals are filtered off, the product is produced.
Category	Pesticide
Toxicity grading	Middle toxic
Acute toxicity	Oral - rat LD50: 2500 mg / kg; Oral - Mouse LD50: 1000 mg / kg
Flammability and hazard characteristics	It produces toxic chloride and nitrogen oxide gases from combustion.
Storage Characteristics	Ventilated, low-temperature ,dry storeroom.It should be stored and transported separately From food raw materials
Extinguishing agent	Dry powder , foam, sand
Usage	dopamine receptor agonist

Niclosamide Preparation Products And Raw materials

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1. Mixed container, we can mix different items in one container.

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