Offer 112809-51-5 C17H11N5 Letrozole

Min.Order / FOB Price:Get Latest Price

1 Kilogram	FOB Price:USD 750.0000 -850.0000

1 Kilogram

FOB Price:USD 750.0000 -850.0000

Min.Order :1 Kilogram
Purity: 98% purity
Payment Terms : L/C,T/T,Other

Keywords

Buy112809-51-5 C17H11N5 99% purity Supply 112809-51-5 with stable production Hot sale !112809-51-5 for pharmaceutical intermediates

Quick Details

Appearance:white to light yellow crystal
Application:112809-51-5 1>Pharmaceutical raw materials and 2>pharmaceutical intermediates, 3>electronic chemicals, 4>fine chemicals 5>Organic Light Emitting Display(Oled) 6>Noble metal catalysts
PackAge:1g;5g;10g;25g;50g;100g;500g;1KG;5KG,25kg,50kg or as customers request
ProductionCapacity:50|Kilogram|Month
Storage:2-8, cold storage, to avoid light storage.
Transportation:BY SEA /BY AIR /BY COURIER

Superiority:

1. ISO 9001 approved, GMP producing standard,Proffesional QA system, our quality is guaranteed.

2. Facotory direct sale, most comptive price ensured;

3. Audited Supplier on lookchem, No trick, No Scam!

4. Enough stock can make sure safe delivery.

5. Complete before and after sale service, welcome your questions and glad to help.

Offer 112809-51-5

Details:

PRODUCT INFORMATION :

Letrozole Basic information

Pharmacological Function Distinctions Between Letrozole and Anastrozole Adverse Reactions and Side Effects Chemical Properties Usage Production Method

Product Name:	Letrozole
Synonyms:	4,4'-(1H-1,2,4-TRIAZOL-1-YLMETHYLENE) BIS-BENZONITRILE;FEMARA;CGS-20267;LETROZOL;LETROZOLE;LetrozoleUsp28;Letrozole99%;CGS-20267, Femara
CAS:	112809-51-5
MF:	C17H11N5
MW:	285.3
EINECS:
Product Categories:	Anti-Cancer;Pharmaceutical material and intermeidates;Active Pharmaceutical Ingredients;Letrozole;Antineoplastic;All Inhibitors;anti-neoplastic;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;API's;APIs;Antibiotics;Aromatics;Heterocycles;ELOXATIN;Anti-cancer&immunity
Mol File:	112809-51-5.mol

Letrozole Chemical Properties

mp	181-183°C
storage temp.	-20°C Freezer
CAS DataBase Reference	112809-51-5(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
Hazardous Substances Data	112809-51-5(Hazardous Substances Data)

MSDS Information

Provider	Language
4,4'-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile	English

Letrozole Usage And Synthesis

Pharmacological Function	Letrozole is a new generation of selective aromatase inhibitors. It is a synthetic benzyl triazole derivative, can inhibit aromatase and decrease estrogen levels, further eliminates the stimulation of estrogen on tumor growth. The activity of letrozole in the body is 150-250 times more than that of the first generation of aromatase inhibitors - aminoglutethimide. Due to its high selectivity, and shall not affect the sugar cortical hormone, mineralocorticoid and thyroid functions, large dosage is of no inhibition for adrenal corticosteroid secretions, therefore, it has a higher therapeutic index. Preclinical studies have shown that Letrozole is of no potential toxicity to each system and target organ in the body, no mutagenic and carcinogenic effect, little side reaction, well tolerated, and compared with other aromatase inhibitors and anti-estrogen drugs, it has a stronger antitumor effect. Applicable to the treatment of advanced breast cancer in postmenopausal patients who anti-estrogen ineffective, and early breast cancer. In December 2005, the British drug and health care products regulatory approved letrozole (furlong) produced by Swiss Novartis used to treat breast cancer patients, and allowed it to treat early invasive breast cancer patients after the surgery caused by positive postmenopausal hormone. This is the second aromatase inhibitors approved by UK after Astrazeneca's Arimidex June in 2005. Two drugs in clinical trials have shown that compared with the current standard Tamoxifen treatment, it can better prevent the risk of breast cancer recurrence.
Distinctions Between Letrozole and Anastrozole	Letrozole tablets: suitable for advanced breast cancer after menopause, most used in the treatment of anti-estrogen treatment failure after second-line therapy. Anastrozole: an effective selective inhibitor for three azole aromatase, it inhibits the aromatase relied by cytochrome P-450, further blocks estrogen biosynthesis, which is the main factor to stimulate breast cancer cell growth. The 50% inhibitory concentration (IC50) value of human placenta aromatase is 15 nmol/L.
Adverse Reactions and Side Effects	Randomized trials show that orally take 2.5 mg of letrozole every day, adverse reactions incidence may be related to the drug is 33%, and is significantly less than that of the AG group which is 46%. Most adverse reactions of letrozole are mild or moderate, mainly include nausea (2% ~ 9%), headache (0% ~ 7%), bone pain (4% ~ 10%), hot flashes (0% ~ 9%) and weight gain (2% ~ 8%), and other rare reactions like constipation, diarrhea, itching, rash, joint pain, chest pain, abdominal pain, fatigue, insomnia, dizziness, edema, hypertension, arrhythmia, thrombosis, difficulty breathing, vaginal bleeding, etc.
Chemical Properties	Melting point is 181～183 oC.
Usage	Pyrrole type aromatization enzyme inhibitors. Used in the treatment of breast cancer. This information is edited by ChemicalBook Xiao Nan.
Production Method	4-bromine methyl phenyl nitrile (I) and triazole react in chloroform, products (Ⅱ) and 4-fluorine benzene nitriles react in dimethyl formamide, generate to letrozole in the presence of potassium tert-butyl alcohol.
Chemical Properties	white to light yellow crystal
Usage	A nonsteroidal aromatase inhibitor structurally related to Fadrozole. Antineoplastic

Letrozole Preparation Products And Raw materials

Raw materials

Potassium tert-butanolate-->3-Amino-5-mercapto-1,2,4-triazole-->4-Cyanobenzyl bromide

COMPANY INFORMATION :

HenNan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .
Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.

superiority :

1. Production capacity: we have three production base with high-tech production equipment and instruments, equipped with professional production personnel, meet your requirements.
2. Quality assurance: we have a first-class testing equipment and testing personnel, in strict accordance with ISO and cGMP standards, ensure that the quality of the shipment.
3.Ultra-low prices, we follow the meager profit but high turnover principle to win more customers, to provide you with quality and cheap products.
4.The best service: we can real-time quotation, tracking service, ensure the safety of the goods to the clients.
5. Customer groups: our clients throughout the world more than 30 countries, high quality products, low price, best service to win the customer's consistent high praise.
If you demand the product, you are welcome to contact us at any time, we guarantee that you seriously every inquiry, give you the fastest reply and the best service.

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