Newblue CHEM----A-8...

Newblue CHEM----A-83-01

Newblue CHEM----A-83-01

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1 Kilogram

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  • Min.Order :1 Kilogram
  • Purity: 98
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Keywords

A-83-01 909910-43-6 good quality

Quick Details

  • Appearance:Colorless to light yellow liquid
  • Application:Water treatment
  • PackAge:20kg/drum, 200kg/drum or 1000kg/IBC Drum
  • ProductionCapacity:10|Metric Ton|Month
  • Storage:Room temperature
  • Transportation:By sea , by air or express

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Details:

A-83-01 Basic information
Product Name: A-83-01
Synonyms: 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide;A 83-01, >=98%;TGF inhibitor A-83-01;3-(6-methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide
CAS: 909910-43-6
MF: C25H19N5S
MW: 421.526
EINECS:  
Product Categories: Protein Kinase;TGF-beta/Smad;Inhibitors
Mol File: 909910-43-6.mol
A-83-01 Structure
 
A-83-01 Chemical Properties
mp  111℃
storage temp.  Store at -20°C
 
Safety Information
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26-36
MSDS Information
 
 
A-83-01 Usage And Synthesis
Usage A 83-01 is a selective inhibitor of TGF-β type I receptor. A 83-01 treatment increases tumor permeability.
Biological Activity Selective inhibitor of TGF- β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC 50 values are 12, 45 and 7.5 nM respectively). Blocks phosphorylation of Smad2 and inhibits TGF- β -induced epithelial-to-mesenchymal transition. Only weakly inhibits ALK-1, -2, -3, -6 and MAPK activity. More potent than SB 431542 (4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol -2-yl]benzamide). Inhibits differentiation of rat induced pluripotent stem cells (riPSCs) and increases clonal expansion efficiency. Helps maintain homogeneity and long-term in vitro self-renewal of human iPSCs.

 

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