COMBRETASTATIN A-4

COMBRETASTATIN A-4
COMBRETASTATIN A-4
COMBRETASTATIN A-4

COMBRETASTATIN A-4

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100 Kilogram

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  • Min.Order :100 Kilogram
  • Purity: 99%
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Keywords

COMBRETASTATIN A-4 117048-59-6 C18H20O5

Quick Details

  • Appearance:powder
  • Application:117048-59-6
  • PackAge:Depended
  • ProductionCapacity:300|Kilogram|Month
  • Storage:Store in dry, dark and ventilated place
  • Transportation:by air or by sea

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COMBRETASTATIN A-4 Basic information
Product Name: COMBRETASTATIN A-4
Synonyms: (Z)-2-Methoxy-5-(3,4,5-Trimethoxystyryl)Phenol;(Z)-2-Methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]phenol,3,4,5-Trimethoxy-3hydroxy-4methoxy-(Z)-stilbene,CS-A4;Combrestatin A4( 2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol );(Z)-2-Methoxy-5-(3,4,5-trimethoxystyryl)phenol ,98%;2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol;3-[(Z)-2-(3,4,5-Trimethoxyphenyl)ethenyl]-6-methoxyphenol;5-[(Z)-2-(3,4,5-Trimethoxyphenyl)ethenyl]-2-methoxyphenol;Combretastatin A4
CAS: 117048-59-6
MF: C18H20O5
MW: 316.3484
EINECS:  
Product Categories: Inhibitors;Combretastatin;Anti-cancer & immunity;API
Mol File: 117048-59-6.mol
COMBRETASTATIN A-4 Structure
 
COMBRETASTATIN A-4 Chemical Properties
mp  84.5-85.5°C
storage temp.  Desiccate at -20°C
 
Safety Information
Hazard Codes  T
Risk Statements  23/24/25-41
Safety Statements  26-36/37-39-45
RIDADR  UN 2811
MSDS Information
 
 
COMBRETASTATIN A-4 Usage And Synthesis
Chemical Properties Crystalline Powder
Usage Combretastatin is a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Induces Mitotic Catastrophe in Chronic Lymphocytic Leukemia Cell Line Independent of Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage. A potent cytotoxic agent which strongly inhibits the polymerization of tubulin by binding to the colchicine site.
Biological Activity Antitumor, antiangiogenic and antimetastatic agent, in vitro and in vivo . Acts by inhibiting tubulin polymerization (IC 50 = 2-3 μ M).

 

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