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pharmaceutical intermediate 51-21-8 qualified of 5-Fluorouracil 5-Fluorouracil china
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CAS NO. |
51-21-8 |
Product Name |
5-Fluorouracil |
Synonyms
|
Ro-2-9757; Phtoruracil; Ulup; 2,4(1H,3H)-Pyrimidinedione,5-fluoro-; Phthoruracil; Uracil, 5-fluoro-; 5-Fluoro-2,4(1H, 3H)-pyrimidinedione; 2,4 (1H, 3H)-Pyrimidinedione, 5-fluoro-; 5-Fluoro-2,4(1H,3H)-pyrimidinedione; Fluoroplex; 5-Fluoracyl; Efudex; Effluderm (free base); 5-Ftouracyl;
5-Fluoropyrimidine-2,4-dione; |
Structure |
|
Purity |
99% |
Molecular Formula |
C4H3FN2O2 |
Molecular Weight |
130.0772 |
Flash Point |
196.5 °C |
Refractive index |
1.542 |
InChI |
InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9) |
Boiling Point |
401.4 °C at 760 mmHg |
Density |
1.53 g/cm3 |
Melting Point |
278-286℃ |
Storage Temperature |
|
Introduction:
Fluorouracil or 5-FU (trademarked as Adrucil(IV), Carac (topical), Efudex and Efudix (topical)) is a drug that is a pyrimidine analog which is used in the treatment of cancer. It is a suicide inhibitor and works through irreversible inhibition ofthymidylate synthase. It belongs to the family of drugs called the antimetabolites.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system.
5-Fluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years, increased understanding of the mechanism of action of 5-FU has led to the development of strategies that increase its anticancer activity. Despite these advances, drug resistance remains a significant limitation to the clinical use of 5-FU. Emerging technologies, such as DNA microarray profiling, have the potential to identify novel genes that are involved in mediating resistance to 5-FU. Such target genes might prove to be therapeutically valuable as new targets for chemotherapy, or as predictive biomarkers of response to 5-FU-based chemotherapy.
Usage:
Fluorouracil (CAS NO.51-21-8) can be used in against cancer for about 40 years, acts in several ways, but principally as a thymidylate synthase inhibitor. It can be used in colorectal cancer and pancreatic cancer,also it can be used for treating actinic (solar) keratoses and some types of basal cell carcinomas of the skin.
Fluorouracil has been given systemically for anal, breast, colorectal,oesophageal, stomach, pancreatic and skin cancers (especially head and neck cancers). It has also been given topically for actinic keratoses, skin cancers and Bowen's disease.
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