Sulfaguanidine

Product information

 

Sulfaguanidine Basic information

sulfanilamide drugs Chemical Properties Application Production methods Category Toxicity grading Acute toxicity Flammability and hazardous characteristics Storage characteristics Extinguishing agent

Product Name:	Sulfaguanidine
Synonyms:	((4-Aminophenyl)sulfonyl)guanidine;((p-Aminophenyl)sulfonyl)guanidine;1-((p-Aminophenyl)sulfonyl)guanidine;1-Amino-4-(([amino(imino)methyl]amino)sulfonyl)benzene;1-Sulfanilylguanidine;4-amino-n-(aminoiminomethyl)-benzenesulfonamid;4-amino-n-(diaminomethylene)-benzenesulfonamid;4-Amino-N-(diaminomethylene)benzenesulfonamide
CAS:	57-67-0
MF:	C7H10N4O2S
MW:	214.24
EINECS:	200-345-9
Product Categories:	Antibiotics for Research and Experimental Use;Biochemistry;Sulfonamides (Antibiotics for Research and Experimental Use);Antibacterial;Antibiotics;Antibiotics A to;Antibiotics N-SAntibiotics;Chemical Structure Class;Inhibits an EnzymeAntibiotics;Interferes with DNA SynthesisSpectrum of Activity;L - ZAntibiotics;Mechanism of Action;Sulfonamides;GANIDAN;pharmaceutical
Mol File:	57-67-0.mol

Sulfaguanidine Chemical Properties

mp	190-193°C
storage temp.	-20°C
Water Solubility	1g/1000mL at 25 ºC
Merck	8908
Stability:	Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference	57-67-0(CAS DataBase Reference)
NIST Chemistry Reference	Sulfaguanidine(57-67-0)
EPA Substance Registry System	Benzenesulfonamide, 4-amino-N-(aminoiminomethyl)- (57-67-0)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	3249
WGK Germany	3
RTECS	WO8575000
F	10
HazardClass	6.1(b)
PackingGroup	III

MSDS Information

Provider	Language
SigmaAldrich	English

Sulfaguanidine Usage And Synthesis

sulfanilamide drugs	Sulfa and Sulfaguanidine have been ever common sulfa drugs. Owing to its relative high toxicity, it is generally not used as the drug of first choice, now they, together with acetaminophen chloride are only used as the intermediates of the manufacturing of sulfa drugs.  Sulfaguanidine is used as sulfa drugs for the treatment of intestinal infections in the earliest time. The molecular structure of sulfaguanidine contains a strongly basic guanidine group with high dissociation property and low lipid solubility. Although there is certain amount which can be absorbed through the gut after oral administration, the amount is not enough to achieve an effective blood concentration, therefore not being used for systemic infections. However, it can be maintained at a high concentration in the intestines, mostly used for the treatment of bacterial infections in the digestive tract such as gastroenteritis and dysentery. When being used in combination with antibacterial synergist trimethoprim (TMP) or di-trimethoprim (DVD), its antibacterial effect was significantly enhanced. Preparation methods: 1. the finished product of sulfaguanidine can be made through the melting of sulfa and guanidine nitrate in the soda and further vacuum condensation. 2. it can be alternatively made from the reaction between acesulfame chloride and guanidine nitrate in the mixed solution of acetone and water in the presence of sodium hydroxide. 3. take p-nitrobenzenesulfonyl chloride as raw material, go through catalytic hydrogenation reaction to produce p-amino benzenesulfonyl chloride and further ammoniation to generate sulfonamides, and then reacted with guanidine nitrate to obtain sulfaguanidine. Drug interactions: 1. Simultaneous administration of urine alkaline drugs can enhance the solubility of this product in alkaline urine and increase the excretion. 2. Sulfaguanidine can’t be used in combination with 4-aminobenzoic acid which can replace this product to be absorbed by bacteria and is mutually antagonistic with each other. It is also not suitable to be used in combination with local anesthetics drugs containing the p-amino-benzoyl group such as procaine, tetracaine and so on. 3. for patients subjecting to administration of estrogen contraceptives, simultaneously prolonged administration can lead to a reduction of the reliability of Sulfaguanidine contraceptive and also increase the chance of non-menstrual bleeding. 4. being used in combination with the light-sensitive drug effect may cause photosensitive additive effect. 5. people subjecting to the treatment of goods have a high demand for vitamin K. This information is edited by Xiongfeng Dai from Chemicalbook.
Chemical Properties	It appears as needle-like crystalline powder with the melting point being 190-193 ℃. 1g of this product can be dissolved in about 1000 ml of water at 25 ℃, dissolved in about 10 ml of water at 100 ℃. It is slightly soluble in ethanol or acetone and easily soluble in dilute hydrochloric acid. It is odorless and tasteless with its color deepened in the case of light.
Application	1. It belongs to sulfa drugs and used for the treatment of bacillary dysentery and enteritis.  2. It can be used for the treatment of intestinal antibacterial infections such as bacterial dysentery enteritis and can also be used to prevent infection before bowel surgery.  3. It is the first-choice of drug for the treatment of leprosy, being suitable for the treatment of various types of leprosy and being able to alleviate the clinical symptoms. It can generally alleviate the mucosal lesions rapidly with the improvement of skin lesions occurring more slowly, with even slower rate in neuropathy, thereby leading to long course. It is easy to produce drug resistance and difficult to cure. In addition, it can also be used for the treatment of dermatitis herpetiformis, lupus, psoriasis, foot fungus disease and malaria. Its preparation is tablet.
Production methods	It can be made through the condensation between sulfa and guanidine nitrate.
Category	Toxic substances.
Toxicity grading	Poisoning.
Acute toxicity	Intraperitoneal - mouse LDL0: 500 mg / kg.
Flammability and hazardous characteristics	It is combustible with combustion producing toxic fumes of nitrogen oxides and sulfur oxides.
Storage characteristics	Treasury: ventilated, low-temperature and dry.
Extinguishing agent	Dry powder, foam, sand, carbon dioxide, water mist.
Chemical Properties	white powder
Usage	antibacterial
Usage	Sulfaguanidine is a sulfonamide based antibiotic drug with potential application in veterinary medicine.

Company Information

 Henan sunlake enterprise corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .

  Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs ,  Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East ,  Africa , South America and some other countries and areas.

    We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you  better with our high - quality products and professional team.

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