Newblue-CHEM Doviti...

Newblue-CHEM Dovitinib

Newblue-CHEM Dovitinib

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1 Kilogram

Negotiable

  • Min.Order :1 Kilogram
  • Purity: 99.0%
  • Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Dovitinib 915769-50-5 C24H29FN6O5

Quick Details

  • Appearance:Solid
  • Application:Organic synthesis
  • PackAge:IN 25kg drums
  • ProductionCapacity:10|Metric Ton|Month
  • Storage:In Room Temperature
  • Transportation:As per the MSDS

Superiority:

Our company engages in Sodium Tripolyphosphate (STPP) and Sodium Hexametabphosphate (SHMP) production; development of noble metal catalysts, synthesis of electronic chemical materials and general chemicals Imp&Exp trading business. The company is located in Zhengzhou High-tech Development Zone with import and export license. We passed ISO 9001:2008 in 2009, and won "High-tech Enterprise" by provincial government in 2013. Our STPP and SHMP has reached an annual output of 30000 tons and has successfully passed SGS, CIQ audits on many occasions. 


In 2011 we entered the fine chemical market of Noble Metal Catalyst ,Organic Phosphine Ligands  and OLED intermediates.With the joint efforts of our senior experts and professional technicians, Newblue has developed more than 500 compounds, which are widely used in the fields of production and life science. The objective of the company is to put quality first and put our customer’s needs first - the satisfaction of our customers is the company's ultimate goal. Improving product quality and service level is our responsibility, and creating more value for our customer’s is our purpose. We are constantly striving to make Henan Newblue a leading chemical supplier, and hope to create a better future with you.

Details:

Dovitinib Basic information
Anticancer drugs
Product Name: Dovitinib
Synonyms: dovitinib;4-Amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone 2-hydroxypropanoate hydrate (1:1:1);Unii-69vky8p7ea;Dovitinib lactate;Dovitinib lactate(TKI258);Propanoic acid, 2-hydroxy-, coMpd. with 4-aMino-5-fluoro-3-[6-(4-Methyl-1-piperazinyl)-1H-benziMidazol-2-yl]-2(1H)-quinolinone, hydrate (1:1:1);Propanoic acid, 2-hydroxy-, coMpd. with 4-aMino-5-fluoro-3-[6-(4-Methyl-1-piperazinyl)-1H-benziMidazol-2-yl]-2(1H)-quinolinone, hydrate;Dovitinib(C3H6O3：H20)=1：1：1
CAS: 915769-50-5
MF: C24H29FN6O5
MW: 500.5226632
EINECS:  
Product Categories: Anti-cancer&immunity;Inhibitors
Mol File: 915769-50-5.mol
Dovitinib Structure
 
Dovitinib Chemical Properties
 
Safety Information
MSDS Information
 
 
Dovitinib Usage And Synthesis
Anticancer drugs Dovitinib is an orally active small molecule multi-targeted tyrosine kinase inhibitor which can act directly on the tumor cells and provide nutritional support for blood vessels and stromal tumor cells, it has inhibition effect on a variety of growth factors such as VEGFR1-3, FGFR1-3, PDGFRB, e-KIT, Ret, TraA and csf-1. At present, Dovitinib is in clinical trail phase III ,clinical studies show that it has significant therapeutic effect on breast cancer, urinary tract carcinoma, prostate cancer, multiple myeloma, melanoma. With the development of clinical researches, cancer treatment is expected to expand its scope. 
Dovitinib performs its anti-tumor effects by anti-angiogenic activity and anti-proliferative survival activity . The drug is used for inoperable / local treatment of advanced hepatocellular carcinoma patients,it requires the lesion diameter greater than 1cm , blood, liver function is good, physical condition is good ,patients do not receive any systemic therapy (allow surgery 4 weeks outside and radiotherapy and intervention ). 
Preparation: use 5-chloro-2-nitroaniline and N- methyl piperazine as raw materials,after substitution,and reduction, form a ring with β- ethoxy -β- imino - propionate hydrochloride .Finally,after cyclization with 2-amino-6-fluorobenzonitrileto, generate Dovitinib , a total yield of 44.1%.
The above information is edited by the chemicalbook of Tian Ye.

 

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