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Chondroitin sulfate 9007-28-7 (C14H21NO14S)n
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Henan Sunlake Enterprise Corporation is located in Henan Province , The central plain of China , Which enjoys favorable geogeaphical position and convenient transportion, The com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .Sunlake is a professional manufacturer engaged in producing and selling chemicals,including Organic & inorganic chemicals , pigments & Dyestuffs , Water treatment chemicals , Food & FEED additives and others . these products have been being well exported to europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.We sincerely welcome foreign friends to visit our plant for cooperation. With the idea of "quality first,credit priority, Excellent service", We are highly acknowledged by customers for good quality and competitive price. More importantly , the company has a strong R & D team, who are professional engineers and scholars with Ph. D. .So we are confident to serve you better with our high - quality products and professional team.We are taking great efforts to provide our customers with demanded goods and professional services, and continuously improve our core ability of competition and get the momentum for sustainable development, and finally make us being a reliable and professional wupplier in international market.We welcome any serious inquiries from all customers of the world, and sincerely hope to cooperate.
Chondroitin sulfate Basic information |
Product Name: | Chondroitin sulfate |
Synonyms: | poly-1(2/3)-n-acetyl-2-amino-2-deoxy-3-o-beta-d-glucopyranurosyl-4-(6)sulfonyl-d-galactose;chondroitinpolysulfate;chondroitinsulfates;chondroitinsulfuricacid;chondroitinsulfuricacids;chonsurid;CHONDROITIN SULPHATE;CHONDROITINE SULPHATE |
CAS: | 9007-28-7 |
MF: | (C14H21NO14S)n |
MW: | 0 |
EINECS: | 232-696-9 |
Product Categories: | APIs;Nutritional Supplements;Nutritional fortification substances;Glycosaminoglycan;Biochemicals Found in Plants;Carbohydrates;GlycosaminoglycanGlycan Component Classes;Glycosaminoglycans;Glycosaminoglycans and Proteoglycans;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors |
Mol File: | Mol File |
Chondroitin sulfate Chemical Properties |
storage temp. | Store at RT. |
CAS DataBase Reference | 9007-28-7(CAS DataBase Reference) |
Safety Information |
Chondroitin sulfate Usage And Synthesis |
General Description |
At room temperature, it is a white powder, odorless, tasteless. It has a strong ability of water absorption. It is highly soluble in water to become a solution with high viscosity. It become unstable upon higher temperatures or acidic condition, primarily being deacetylated or being degraded into monosaccharide or smaller molecular-weight polysaccharide. It is not soluble in organic solvent like ethanol, acetone and ether. Its salt is quite stable to heat without being destroyed when heated to 80 °C. Chondroitin sulfate is a mixture of acid mucopolysaccharides extracted from the cartilage of pigs, cattle, chicken, and shark cartilage. According to their differences in chemical composition and structure, it is divided into A, B, C, D, E, F, H, etc. It mainly contains mucopolysaccharides such as chondroitin sulfate A and chondroitin sulfate C. Both chondroitin sulfate A and C contain D- glucuronic acid and 2-hydroperoxy group-deoxy-D-galactose, and contain equal amounts of acetyl and sulfuric acid residue. The only difference between them is the different position of sulfuric acid ester on the hexosamine residues. Chondroitin sulfate A can enhance the activity of lipase, causing the decomposition of triglyceride in chylomicron so that the blood will become clean due to the decrease of chylomicrons. It has anticoagulant and antithrombotic effect, and thus is clinically used for the treatment of coronary artery disease, elevated blood lipids and cholesterol, angina, neuralgia, myocardial ischemia and myocardial infarction embolism. It can also be used for prevention and treatment of hearing disorders and migraine caused by streptomycin, neuropathic pain, elderly pain of shoulder, backache, arthritis and hepatitis and skin cosmetics. It is reported that chondroitin sulfate can also be effective on improving and repairing of articular cartilage, synovium, keep the lubrication between the joints cartilages and making it elastic, alleviating joint pain and inflammation. Moreover, it also has special efficacy on symptoms located in tendons, ligaments, and diaphragm. Chondroitin sulfate is also an important component of eye tissue. It can boost the water metabolism in corneal, improve the microcirculation, protect the cornea and promote the repair function of corneal tissue. It can also form a protective form in the corneal surface to prevent water evaporation which can effectively relieve visual fatigue and symptoms of dry eye; In additions to its anti-bacterial and anti-inflammatory effect, taurine can also participates in a lot of physiological activities in eye tissue and promote metabolism, alleviate visual fatigue. |
Function |
1. Chondroitin sulfate is mucopolysaccharides-class substance extracted from animal cartilage. It has an important role in prevention and treatment of cardiovascular disease, joint disease, and currently is an important biochemical product on the market. 2. As a health food or drugs, chondroitin sulfate has been long used to prevention and treatment of coronary heart disease, angina, myocardial infarction, coronary atherosclerosis, myocardial and ischemia with no significant side effects. It can significantly reduce the incidence and mortality of coronary heart disease. Long-term clinical application finds that the deposited fat can in the walls of arteries and veins can be effectively reduced or removed, which can significantly lower plasma cholesterol level, and thus preventing the formation of atherosclerosis. 3. Chondroitin sulfate can also be used for the treatment of neuropathic pain, nerve migraine headaches, joint pain, arthritis and scapular joint pain, pain after abdominal operation. 4. It can be used for prevention and treatment of hearing impairment caused by streptomycin, and hearing difficulties, tinnitus caused by a variety of noise with a significant effect. 5. It also has adjuvant therapy on chronic nephritis, chronic hepatitis, keratitis and corneal ulcers. 6. It is reported in recent years that, the chondroitin of shark cartilage has anti-tumor effect. In addition, chondroitin sulfate is also used for cosmetics and as healing agent of traumatic wound. Chondroitin sulfate is a kind of acidic mucopolysaccharides as an important component of ocular tissues. It can promote and improve the water metabolism of the cornea which is suitable for treating eye fatigue and dry eye syndrome. Figure 1 Chondroitin sulfate supplied in Sigma Company (US) The above information is edited by the Chemicalbook of Dai Xiongfeng. |
Pharmacology and toxicology |
Chondroitin sulfate is widely existed in human and animal cartilage. Its pharmaceutical preparation mainly contains two isomers: chondroitin sulfate A and chondroitin sulfate C. The content of chondroitin sulfate is different in animal cartilage of different breeds and ages. Its pharmacological effects performance is as follows: Chondroitin sulfate can clear the blood lipid and lipoprotein, clear the cholesterol on blood vessels around the heart, prevent atherosclerosis and increase the turnover rate of lipids and fatty acids inside the cell. Chondroitin sulfate can effectively prevent and treat coronary heart disease. It has effect of anti-atherosclerosis and anti-plaque formation on experimental atherosclerosis mode. It can increase the circulation |
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