cas:382180-17-8 cas:382180-17-8 C13H19N3O3 C13H19N3O3
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Pyroxamide Basic information |
Product Name: | Pyroxamide |
Synonyms: | Octanediamide, N1-hydroxy-N8-3-pyridinyl-;N-Hydroxy-N'-3-pyridinyloctanediamide;Pyroxamide;Pyroxamide;2-[1-carbaMoyl-N-(2H-pyran-2-yl)forMaMido]-N-hydroxy-N'-(pyridin-3-yl)octanediaMide;PyroxaMide (NSC 696085);N1-Hydroxy-N8-3-pyridinyl-octanediamide |
CAS: | 382180-17-8 |
MF: | C13H19N3O3 |
MW: | 265.30826 |
EINECS: | |
Product Categories: | |
Mol File: | 382180-17-8.mol |
Pyroxamide Chemical Properties |
storage temp. | 20°C |
Pyroxamide Usage And Synthesis |
Usage | Pyroamide is a histone decetylase inhibitor (HDCi), a novel class of anti-neoplastic agent that acts by enhancing acetylation of histones, promoting uncoiling of chromatin and activation of genes imp licated in the regulation of cell survival such as poliferation, differentiation and apoptosis. Pyroamide is known to potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells. |
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