CAS:58880-19-6 C17H...

CAS:58880-19-6 C17H22N2O3
CAS:58880-19-6 C17H22N2O3
CAS:58880-19-6 C17H22N2O3

CAS:58880-19-6 C17H22N2O3

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500 Gram

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Keywords

CAS:58880-19-6 CAS:58880-19-6 C17H22N2O3 C17H22N2O3

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  • Appearance:white poweder
  • Application:CAS:58880-19-6 C17H22N2O3
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TRICHOSTATIN A Basic information
Product Name: TRICHOSTATIN A
Synonyms: (2E,4E,6R)-7-(4-(DIMETHYLAMINO)PHENYL)-N-HYDROXY-4,6-DIMETHYL-7-OXO-2,4-HEPTADIENAMIDE;7-[4-(DIMETHYLAMINO)PHENYL]-N-HYDROXY-4,6R-DIMETHYL-7-OXO-2E,4E-HEPTADIENAMIDE;4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXAHEPTA-2,4-DIENOHYDROXAMIC ACID;4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXOHEPTA-2,4-DIENOHYDROXAMIC ACID;7-(4-(dimethylamino)phenyl)-n-hydroxy-4,6-dimethyl-7-oxo-4-heptadienamide;TSA;TRICHOSTATIN A;TRICHOSTATIN A, STREPTOMYCES SPECIES
CAS: 58880-19-6
MF: C17H22N2O3
MW: 302.37
EINECS:  
Product Categories: Anti Cancer Research;Inhibitor;antibiotic;API;Inhibitors
Mol File: 58880-19-6.mol
TRICHOSTATIN A Structure
 
TRICHOSTATIN A Chemical Properties
mp  140-143℃
density  1.139
refractive index  136 ° (C=0.3, MeOH)
storage temp.  −20°C
solubility  ethanol: 1 mg/mL
Merck  9649
 
Safety Information
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38-43
Safety Statements  26-36
WGK Germany  3
RTECS  MI5215000
MSDS Information
Provider Language
SigmaAldrich English
 
TRICHOSTATIN A Usage And Synthesis
Chemical Properties Solid
Usage Trichostatin A is a known inhibitor of fibrosis in vitro and in vivo, and is used as an anticancer agent. Potent differentiation inducer of friend leukemic cells.
Usage Trichostatin A is a histone deacetylase inhibitor that enhances the cytotoxic efficacy of anticancer drugs that target DNA. Trichostatin A displays antifungal, antiprotozoan and antitumour activity
Usage Trichostatin A is a histone deacetylase inhibitor that enhances the cytotoxic efficacy of anticancer drugs that target DNA. Trichostatin A displays antifungal, antiprotozoan and antitumor activity
Biological Activity Selective and potent inhibitor of histone deacetylase (K i = 3.4 nM). Active in vivo . Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells.

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Details:

 

TRICHOSTATIN A Basic information
Product Name: TRICHOSTATIN A
Synonyms: (2E,4E,6R)-7-(4-(DIMETHYLAMINO)PHENYL)-N-HYDROXY-4,6-DIMETHYL-7-OXO-2,4-HEPTADIENAMIDE;7-[4-(DIMETHYLAMINO)PHENYL]-N-HYDROXY-4,6R-DIMETHYL-7-OXO-2E,4E-HEPTADIENAMIDE;4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXAHEPTA-2,4-DIENOHYDROXAMIC ACID;4,6-DIMETHYL-7-[P-DIMETHYLAMINOPHENYL]-7-OXOHEPTA-2,4-DIENOHYDROXAMIC ACID;7-(4-(dimethylamino)phenyl)-n-hydroxy-4,6-dimethyl-7-oxo-4-heptadienamide;TSA;TRICHOSTATIN A;TRICHOSTATIN A, STREPTOMYCES SPECIES
CAS: 58880-19-6
MF: C17H22N2O3
MW: 302.37
EINECS:  
Product Categories: Anti Cancer Research;Inhibitor;antibiotic;API;Inhibitors
Mol File: 58880-19-6.mol
TRICHOSTATIN A Structure
 
TRICHOSTATIN A Chemical Properties
mp  140-143℃
density  1.139
refractive index  136 ° (C=0.3, MeOH)
storage temp.  −20°C
solubility  ethanol: 1 mg/mL
Merck  9649
 
Safety Information
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38-43
Safety Statements  26-36
WGK Germany  3
RTECS  MI5215000
MSDS Information
Provider Language
SigmaAldrich English
 
TRICHOSTATIN A Usage And Synthesis
Chemical Properties Solid
Usage Trichostatin A is a known inhibitor of fibrosis in vitro and in vivo, and is used as an anticancer agent. Potent differentiation inducer of friend leukemic cells.
Usage Trichostatin A is a histone deacetylase inhibitor that enhances the cytotoxic efficacy of anticancer drugs that target DNA. Trichostatin A displays antifungal, antiprotozoan and antitumour activity
Usage Trichostatin A is a histone deacetylase inhibitor that enhances the cytotoxic efficacy of anticancer drugs that target DNA. Trichostatin A displays antifungal, antiprotozoan and antitumor activity
Biological Activity Selective and potent inhibitor of histone deacetylase (K i = 3.4 nM). Active in vivo . Potential anti-cancer agent. Induces accelerated dedifferentiation of primordial germ cells (PGCs) into embryonic germ (EG) cells.

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