Endoxifen (E-isomer...

Endoxifen (E-isomer hydrochloride)

Endoxifen (E-isomer hydrochloride)

Min.Order / FOB Price:Get Latest Price

500 Milligram

Negotiable

  • Min.Order :500 Milligram
  • Purity: More than 98%
  • Payment Terms : T/T

Keywords

Endoxifen（(E-isomer） E-Endoxifen E-Endoxifen ≥98% (HPLC)

Quick Details

  • Appearance:white solid powder
  • Application:only used in researh.
  • PackAge:according to the clients requirement
  • ProductionCapacity:3|Kiloliter|Month
  • Storage:Store at -20°C
  • Transportation:by sea or by air

Superiority:

1.we are direct manufacturer and we have 7 years experience in this aera.
2.we can provide competitive price for every customer and guarantee the quality of our goods.
3.Specials are possible when client's order is big enough, including the discount policy;
4.we promise we will return your money if our product don't have effect.
5.Our company promise to deliver clients' package to his hands safely, or we'll cover the total loss and reship in time;
6. Our customers may buy our products again after they use our sample.

In stock ,If you need HNMR\HPLC,please contact us!

Details:

Endoxifen (E-isomer hydrochloride) is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM). Target: Estrogen Receptor/ERR Endoxifen is considered a prodrug, since it has a much higher potency for the estrogen receptor than its parent drug. Endoxifen inhibits the hERG channel protein trafficking to the plasma membrane in a concentration-dependent manner with Endoxifen being more potent than Tamoxifen. [1] Endoxifen is also shown to be a more potent inhibitor of estrogen target genes when ERβ is expressed. Additionally, low concentrations of Endoxifen observed in Tamoxifen treated patients with deficient CYP2D6 activity (20 to 40 nM) markedly inhibit estrogen-induced cell proliferation rates in the presence of ERβ, whereas much higher Endoxifen concentrations are needed when ERβ is absent.[2]

 

Kailiqi Biopharma is a professional manufacturer specialized in the production and distribution of active pharmaceutical ingredients and intermediates.. We develop produce and distribute high quality pharmaceuticals, intermediates, special chemicals and OLED materials & OLED intermediates and other fine chemicals. Kailiqi Biopharma consists a team of professional analytical department complete QC&QA under strict SOPs, experienced sale and after-sale service, efficient logistic support. 
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