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P-BROMOCINNAMYLAMINO SOQUINOLINESULFONMIDE H-89 DIHYDROCHLORIDE
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3.Route of synthesis (ROS)
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5.Nuclear Magnetic Resonance(NMR)
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Product Name: | H-89 dihydrochloride |
Synonyms: | H-89;H-89 DIHYDROCHLORIDE;H-89 HYDROCHLORIDE;N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE;N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE 2HCL;N-[2-(P-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE, DIHYDROCHLORIDE;N-(2-[P-BROMOCINNAMYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE;N-[2-[P-BROMOCINNAMYLAMINO]-ETHYL]-5-ISOQUINOLINESULFONMIDE |
CAS: | 127243-85-0 |
MF: | C20H20BrN3O2S |
MW: | 446.36 |
EINECS: | |
Product Categories: | Protein Kinase Inhibitors and Activators;Inhibitor |
Mol File: | 127243-85-0.mol |
H-89 dihydrochloride Chemical Properties |
mp | 195-200°C |
density | 1.436 |
storage temp. | 2-8°C |
solubility | H2O: ≥10 mg/mL |
form | powder |
color | off-white |
CAS DataBase Reference | 127243-85-0(CAS DataBase Reference) |
Safety Information |
Safety Statements | 22-24/25 |
WGK Germany | 3 |
H-89 dihydrochloride Usage And Synthesis |
Chemical Properties | White Solid |
Usage | Selective inhibitor of Protein Kinase A (cyclic AMP-dependeant Protein Kinase) with an inhibitory constant of 0.0048 uM |
Biological Activity | Protein kinase A inhibitor that also inhibits several other kinases (IC 50 values are 80, 120, 135, 270, 2600 and 2800 nM for S6K1, MSK1, PKA, ROCKII, PKB α and MAPKAP-K1b). |
H-89 dihydrochloride Preparation Products And Raw materials |
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