sale 909910-43-6 C25H19N5S A-83-01 from China Wholesale
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| 500 Gram |
FOB Price:USD 750.0000 -850.0000 |
- Min.Order :500 Gram
- Purity: 98%
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- Appearance:white powder
- Application:909910-43-6
- PackAge:1g;5g;10g;25g;50g;100g;500g;1KG;5KG,25kg,50kg or as customers request
- ProductionCapacity:100|Kilogram|Month
- Storage:2-8, cold storage, to avoid light storage.
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Our Services（1）High quality from own laboratory（2）Competitive price in China market.（3）mature Technical support（4）Fast delivery and shipping.
superiority
1. Production capacity: we have three production base with high-tech production equipment and instruments, equipped with professional production personnel, meet your requirements.
2. Quality assurance: we have a first-class testing equipment and testing personnel, in strict accordance with ISO and cGMP standards, ensure that the quality of the shipment.
3.Ultra-low prices, we follow the meager profit but high turnover principle to win more customers, to provide you with quality and cheap products.
4.The best service: we can real-time quotation, tracking service, ensure the safety of the goods to the clients.
5. Customer groups: our clients throughout the world more than 30 countries, high quality products, low price, best service to win the customer's consistent high praise.
If you demand the product, you are welcome to contact us at any time, we guarantee that you seriously every inquiry, give you the fastest reply and the best service.
Details:
Our Services
（1）High quality from own laboratory
（2）Competitive price in China market.
（3）mature Technical support
（4）Fast delivery and shipping.
superiority
1. Production capacity: we have three production base with high-tech production equipment and instruments, equipped with professional production personnel, meet your requirements.
2. Quality assurance: we have a first-class testing equipment and testing personnel, in strict accordance with ISO and cGMP standards, ensure that the quality of the shipment.
3.Ultra-low prices, we follow the meager profit but high turnover principle to win more customers, to provide you with quality and cheap products.
4.The best service: we can real-time quotation, tracking service, ensure the safety of the goods to the clients.
5. Customer groups: our clients throughout the world more than 30 countries, high quality products, low price, best service to win the customer's consistent high praise.
If you demand the product, you are welcome to contact us at any time, we guarantee that you seriously every inquiry, give you the fastest reply and the best service.
| A-83-01 Basic information |
| Product Name: | A-83-01 |
| Synonyms: | 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide;A 83-01, >=98%;TGF inhibitor A-83-01;3-(6-methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-carbothioamide |
| CAS: | 909910-43-6 |
| MF: | C25H19N5S |
| MW: | 421.526 |
| EINECS: | |
| Product Categories: | Protein Kinase;TGF-beta/Smad;Inhibitors |
| Mol File: | 909910-43-6.mol |
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| A-83-01 Chemical Properties |
| mp | 111℃ |
| storage temp. | Store at -20°C |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36 |
| A-83-01 Usage And Synthesis |
| Usage | A 83-01 is a selective inhibitor of TGF-β type I receptor. A 83-01 treatment increases tumor permeability. |
| Biological Activity | Selective inhibitor of TGF- β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC 50 values are 12, 45 and 7.5 nM respectively). Blocks phosphorylation of Smad2 and inhibits TGF- β -induced epithelial-to-mesenchymal transition. Only weakly inhibits ALK-1, -2, -3, -6 and MAPK activity. More potent than SB 431542 (4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol -2-yl]benzamide). Inhibits differentiation of rat induced pluripotent stem cells (riPSCs) and increases clonal expansion efficiency. Helps maintain homogeneity and long-term in vitro self-renewal of human iPSCs. |
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