Pritelivir

Pritelivir

Pritelivir

Min.Order / FOB Price:Get Latest Price

1 Kilogram

FOB Price:USD 10.0000 -100.0000

  • Min.Order :1 Kilogram
  • Purity: >99%
  • Payment Terms : T/T

Keywords

BAY-57-1293 BAY-57-1293;Pritelivir;N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide;Pritelivir,BAY-57-1293;Benzeneacetamide, N-[5-(aminosulfonyl)-4-methyl-2-thiazolyl]-N 348086-71-5

Quick Details

  • Appearance:off white powder
  • Application:HSV helicase primase,inhibators
  • PackAge:100g,500g,1kg,25kg
  • ProductionCapacity:100|Kilogram|Month
  • Storage:Dry seal
  • Transportation:dry seal

Superiority:

low price, high quality!

Details:

BAY 57-1293 represents a new class of potent inhibitors of herpes simplex virus (HSV) that target the virus helicase primase complex.
IC50 Value: 20 nM (HSV-1) [1]
Target: HSV
in vitro: BAY 57-1293 is nearly two orders of magnitude more potent than acyclovirin vitro and the superiority was even more prominent when the viral load was increased (BAY 57-1293 IC50 = 12 nM, 20 nM and 50 nM; acyclovir IC50 = 1uM, 3M and 10 50 uM at a multiplicity of infection (m.o.i.) of 0.0025, 0.02 and 0.2, respectively). A minor increase in IC50 values at higher viral loads was observed for all thiazolyl compounds listed in Table 1. BAY 57-1293 was also active against porcine (IC50 = 5 uM) and bovine (IC50 = 0.12 uM) herpes strains [1].
in vivo: Delayed treatment with BAY 57-1293 (20 mg/kg 2× daily per os, treatment day 4-14) abrogates progression of disease symptoms (mean of 10 animals per group) of HSV-2 infected guinea pigs within 1 d of treatment and healing is observed subsequently, whereas a 7.5 fold higher dose of valacyclovir (150 mg/kg 2× daily) shows marginal therapeutic efficacy compared with placebo [1]. The compound given orally, or intraperitoneally once per day at a dose of 15 mg/kg for 4 successive days was equally effective or superior to a much higher dose of famciclovir (1mg/ml, i.e. approximately 140-200mg/kg/day) given in the drinking water for 7 consecutive days, which, in our hands, is the most effective method for administering famciclovir to mice [2].
Toxicity: Exploratory toxicology and safety pharmacology studies did not reveal any safety relevant findings at 30, 100 and 300 mg/kg BAY 57-1293 (once daily per os) in a 4-week chronic toxicity study in dogs. However, administration of the same dose to rats for 4 weeks resulted in a dose-dependent transitional hyperplasia of the urinary bladder epithelium [1].

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