Avermectin A1a,25-cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)- Avermectin A1a doramectin
The Doramectin, with the CAS registry number 117704-25-3, belongs to the product categories of Antiparasitic; Intermediates & Fine Chemicals; Pharmaceuticals. Its systematic name is called (2alphaE,4E,5'S,6S,6'R,7S,8E,11R,13S,15S,17alphaR,20R,20alphaR,20betaS)-6'-cyclohexyl-20,20beta-dihydroxy-5',6,8,19-tetramethyl-17-oxo-5',6,6',10,11,14,15,17,17alpha,20,20alpha,20beta-dodecahydro-2H,7H-spiro[11,15-methanofuro[4,3 ,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside. This chemical's classification codes are Anthelmintics; Anti-Anxiety Agents; Anti-Infective Agents; Anticonvulsants; Antiparasitic Agents; Antiparasitic [veterinary]; Central Nervous System Agents; Central Nervous System Depressants; Insecticides; Pesticides; Psychotropic Drugs; Tranquilizing Agents.
Physical properties of Doramectin: (1)ACD/LogP: 6.06; (2)# of Rule of 5 Violations: 3; (3)ACD/LogD (pH 5.5): 7; (4)ACD/LogD (pH 7.4): 7; (5)ACD/BCF (pH 5.5): 161310; (6)ACD/BCF (pH 7.4): 161308; (7)ACD/KOC (pH 5.5): 185875; (8)ACD/KOC (pH 7.4): 185872; (9)#H bond acceptors: 14; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 10; (12)Index of Refraction: 1.58; (13)Molar Refractivity: 237.858 cm3; (14)Molar Volume: 714.817 cm3; (15)Surface Tension: 54.231 dyne/cm; (16)Density: 1.258 g/cm3; (17)Flash Point: 274.409 °C; (18)Enthalpy of Vaporization: 159.764 kJ/mol; (19)Boiling Point: 967.377 °C at 760 mmHg; (20)Vapour Pressure: 0 mmHg at 25°C.
Doramectin (Dectomax) is a veterinary drug approved by the Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle. It is used for the treatment and control of internal parasitosis (gastrointestinal and pulmonary nematodes), ticks and mange (and other ectoparasites). Doramectin is also available for horses as an oral flavored bioadhesive gel under the name Doraquest L.A. Oral Gel. It can be used to control and treat internal parasites as roundworms, lungworms and some external parasites.
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible).
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