(-)scopolamine N-butyl bromide

product Name

(-)scopolamine N-butyl bromide

Synonyms

Scopolamine Butylbromide; N-butylhyoscinium bromide; hyoscine butylobromide; Hyoscine-N-Butyl Bromide; Hyoscine butylbromide; (1S,2R,4S,5S)-9-butyl-7-[(3-hydroxy-2-phenylpropanoyl)oxy]-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane bromide; (1S,2R,4S,5S)-9-butyl-7-{[(2S)-3-hydroxy-2-phenylpropanoyl]oxy}-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane bromide; Hyoscinen butylbromide

Molecular Formula

C₂₁H₃₀BrNO₄

Molecular Weight

440.3712

InChI

InChI=1/C21H30NO4.BrH/c1-3-4-10-22(2)17-11-15(12-18(22)20-19(17)26-20)25-21(24)16(13-23)14-8-6-5-7-9-14;/h5-9,15-20,23H,3-4,10-13H2,1-2H3;1H/q+1;/p-1/t15 ,16-,17+,18+,19-,20+,22 ;/m1./s1

CAS Registry Number

149-64-4

EINECS

205-744-1

Modular Structure

ITEM TESTED

STANDARD

  Characters

  Appearance

White or almost white crystalline powder

  Solubility

Freely soluble in water and methylene chloride, sparingly soluble in ethanol

  Identification

  C. Infrared spectral compare

Complies with the spectrum obtained with Hyoscine Butylbromide(CRS)

  F. Reaction for (a) Bromides

Gives positive reaction for bromides

  Solution S

  Appearance of Solution S

Solution S is clear and colorless

  pH of solution S

5.5~6.5

  Specific Optical Rotation of Solution S

-18°~ -20°

  Hyoscine and other related substances (by LC)

  i. Area of Impurity A peak compared to area   

   of reference solution (b)

not more than 0.1%

  ii. Area of Impurity B,C,D,E,F&G peak

    compared to area of reference solution (a)

for each impurity:not more than 0.2%

  iii. Area of any other impurity peak

    compared to area of reference solution (b)

for each impurity: not more than 0.1%

  iv. Area of total impurities peaks compared   

    to twice the area of reference solution (a)

not more than 0.4%

  Loss on Drying

2.5%max.

  Sulphated Ash

0.1%max.

  Assay – potentiometric

98.0% ~ 101.0%

  Residual Solvents

  a. Methanol

3000 max.

  b. Chloroform

60 max.