2-Methoxyestradiol 362-07-2 CAS NO.362-07-2

Name:

Estra-1,3,5(10)-triene-3,17-diol,2-methoxy-, (17b)- (Related Reference)

Molecular Formula:

C₁₉H₂₆O₃

CAS Registry Number:

362-07-2

Synonyms:

Estra-1,3,5(10)-triene-3,17b-diol, 2-methoxy- (7CI,8CI); Estradiol, 2-methoxy- (6CI); 2-Hydroxyestradiol 2-methyl ether; 2-Methoxyestra-1,3,5(10)-triene-3,17b-diol; NSC 659853; Panzem;

InChI:

InChI=1/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12-,13+,15-,18-,19-/m0/s1

Molecular Structure:

 

This structure is also available as a 2d Mol file

Chemical Properties

Appearance:

Off-white solid

Molecular Weight:

302.41

Density:

1.178g/cm³

Boiling Point:

464.4°Cat760mmHg

Melting Point:

188-190°C

Flash Point:

234.7°C

Storage Temperature:

−20°C

Refractive index:

1.586

Solubility:

DMSO: 10 mg/mL

Biological Activity:

Apoptotic, antiproliferative and antiangiogenic agent, in vitro and in vivo ; acts via an estrogen receptor-independent mechanism. Induces p53-induced apoptosis via two pathways: activation of p38 and NF- κ B; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation. Also upregulates death receptor 5 and binds to tubulin, inhibiting its assembly.

Usage:

 2-Methoxyestradiol (CAS.362-07-2) is a natural metabolite which is devoid of estrogenic activity. It is inhibits cell proliferation and angiogenesis.

Safety Data of 362-07-2

Risk Codes:

R23/24/25

Safety Statements:

22-26-36/37/39-45-53-36

MSDS infomation:

Estra-1,3,5(10)-triene-3,17-diol,2-methoxy-, (17b)- (362-07-2).msds

Product name: 2-Methoxyestradiol 

Formula:C₁₉H₂₆O₃ 
weight:302.41 
CAS:362-07-2