Guanidine hydrochloride CAS NO.50-01-1

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• ProName: Guanidine hydrochloride
• CasNo: 50-01-1
• Molecular Formula: CH6ClN3
• Appearance: standardized look
• Application: 1, Organic intermediates 2, synthetic...
• PackAge: Standard Packing
• Purity: 98%-101.0%
• Storage: 2-8 ℃
• Transportation: Air, sea, express delivery
• LimitNum: 0

Guanidine hydrochloride Basic information

Drug intermediates Preparation Application
Product Name: Guanidine hydrochloride
Synonyms: guanidine,monohydrochloride;guanidinechloride;Guanidinemonohydrochloride;guanidiniumhydrochloride;usafek-749;CARBAMIDINE HYDROCHLORIDE;IMINOUREA HYDROCHLORIDE;GUANIDINIUM CHLORIDE
CAS: 50-01-1
MF: CH6ClN3
MW: 95.53
EINECS: 200-002-3
Product Categories: Pharmaceutical Intermediates;Miscellaneous Biochemicals;proteinmod
Mol File: 50-01-1.mol
Guanidine hydrochloride Structure
Guanidine hydrochloride Chemical Properties
mp 180-185 °C(lit.)
density 1.18 g/mL at 25 °C(lit.)
refractive index n20/D 1.465
storage temp. Store at RT.
solubility H2O: 6 M, clear, colorless
Water Solubility 2280 g/L (20 oC)
Sensitive Hygroscopic
Merck 14,4562
BRN 3591990
Stability: Stable. Hygroscopic. Incompatible with strong oxidizing agents.
CAS DataBase Reference 50-01-1(CAS DataBase Reference)
EPA Substance Registry System Guanidine, monohydrochloride(50-01-1)
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-36/38
Safety Statements 26-36-22
WGK Germany 1
RTECS MF4300000
F 3-10
HS Code 29252000

Guanidine hydrochloride Usage And Synthesis
Application Guanidine hydrochloride is used in RNA isolation to dissociate nucleoproteins and inhibit RNase. 
Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.
Drug intermediates Guanidine hydrochloride drug used primarily as an intermediate in the manufacture of sulfadiazine, an important raw material sulfamethyldiazine, sulfamethazine and folic acid.
Guanidine hydrochloride (or guanidine nitrate) and ethyl cyanoacetate reaction, cyclization of 2,4-diamino-6-hydroxy pyrimidine, folic acid for the synthesis of antianemic. Furthermore guanidine hydrochloride also used synthetic anti-static agent.
Preparation In Dicyanodiamide and ammonium (Ammonium chloride) as raw material, melt reaction at 170-230 ℃, guanidine hydrochloride obtained crude, refined products.
Chemical Properties White cryst. powder
Usage cholinergic
Usage Guanidine has a good bacterial and fungicidal efficacy when used in low concentration and can also be used as disinfectant.
Guanidine hydrochloride Preparation Products And Raw materials
Preparation Products 2-Aminopyrimidine-->5-Amino-2-chloropyrimidine-->2,5-Diamino-4,6-dichloropyrimidine-->7-(TRIFLUOROMETHYL)-3-IODOIMIDAZO[1,2-A]PYRIMIDINE-->3-Bromo-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine-->5-AMINO-2-FLUOROPYRIMIDINE-->2-Chloro-5-nitropyrimidine-->9-ETHYLGUANINE-->Guanidine carbonate-->FORMAMIDINE HYDROCHLORIDE-->2-Amino-5-pyrimidinecarboxyaldehyde-->ISOXANTHOPTERIN-->2-AMINO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER-->2-Aminopyrimidine-5-carboxylic acid-->2-AMINO-6-HYDROXY-PYRIMIDINE-4-CARBOXYLIC ACID-->2-Amino-5-nitropyrimidine-->2-Amino-4-chloro-6-methylpyrimidine-->2-amino-6-chloropyrimidin-4(3H)-one-->GUANINE SULFATE-->2,4-DIAMINO-1,3,5-TRIAZINE-->2-Amino-6-methyl-4-pyrimidinol-->Amiloride hydrochloride-->2-Amino-6-hydroxypyrimidin-4(3H)-one ,97%-->2,4-Diaminopyrimidine-->shark soft bone preparation-->6-HYDROXY-2,4,5-TRIAMINOPYRIMIDINE-->Guanidine phosphate
Raw materials Ammonium chloride