Pentamidine isethionate 140-64-7 C23H36N4O10S2
Pentamidine isethionate Basic information |
Product Name: | Pentamidine isethionate |
Synonyms: | 1,5-BIS(P-AMIDINOPHENOXY)PENTANE BIS(2-HYDROXYETHANESULFONATE SALT);1,5-BIS[P-AMIDINOPHENOXY]PENTANE BIS[2-HYDROXYETHANESULFONATE SALT] ISETHIONATE SALT;4,4'-(PENTAMETHYLENEDIOXY)DIBENZAMIDE BIS(2-HYDROXYETHANESULFONATE);4,4'-(PENTAMETHYLENEDIOXY)DIBENZAMIDINE, BIS-2-HYDROXYETHANESULFONATE;PENTAMIDINE ISETHIONATE;PENTAMIDINE ISETHIONATE SALT;4,4'-(pentamethylenedioxy)dibenzamidine bis(2-hyd;pentamidine isetionate |
CAS: | 140-64-7 |
MF: | C23H36N4O10S2 |
MW: | 592.68 |
EINECS: | 205-424-1 |
Product Categories: | API;HIV/AIDS/Related Products;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals |
Mol File: | 140-64-7.mol |
Pentamidine isethionate Chemical Properties |
mp | 188-194 °C(lit.) |
storage temp. | −20°C |
form | powder |
Merck | 13,7192 |
CAS DataBase Reference | 140-64-7(CAS DataBase Reference) |
EPA Substance Registry System | Ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-[1,5-pentanediylbis( oxy)]bis[benzenecarboximidamide] (2:1)(140-64-7) |
Safety Information |
Hazard Codes | Xi |
Risk Statements | 36/37/38-43 |
Safety Statements | 26-36/37 |
RIDADR | 3249 |
WGK Germany | 3 |
RTECS | CV6500000 |
HazardClass | 6.1(b) |
PackingGroup | III |
Pentamidine isethionate Usage And Synthesis |
Usage | Has been widely used as a drug to treat protozoal diseases, such as malaria, amoebic dysentery and trypanosomiasis. It has also been shown to be effective for both prophylaxis of pneumocystic carinii pneumonia (PCC). |
Usage | Antiparasitic |
General Description | Odorless white or almost white crystals or powder. Odor also reported as a slight butyric odor. Very bitter taste. pH (5% aqueous solution) 4.5-6.5. |
Air & Water Reactions | Hygroscopic. May be sensitive to prolonged exposure to air. Aqueous solutions deteriorate on storage. Water soluble. |
Reactivity Profile | Can decompose on prolonged exposure to light. |
Fire Hazard | Flash point data for Pentamidine isethionate are not available; however, Pentamidine isethionate is probably combustible. |
Biological Activity | Antimicrobial. Neuroprotective; inhibits constitutive nitric oxide synthase in the brain and acts as a NMDA glutamate receptor antagonist. |
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