50-28-2 Estradiol Estradiol CAS:50-28-2
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Item |
Specifications |
Results |
Appearance |
White or almost white crystalline powder |
Conform |
Solubility |
Practically insoluble in water, soluble in acetone, sparingly soluble in alcohol, slightly soluble in methylene chloride |
Conform |
Identification |
IR spectrum of the sample corresponds to that of the reference standard |
Conform |
Melting point |
175~180℃ |
176~178℃ |
Specific rotation |
+76.0°~ +83.0° |
+77.8° |
Water |
2.9~3.5% |
3.0% |
Related substances |
Individual known impurity≤0.3% |
0.16% |
Any other impurity≤0.1% |
0.05% |
|
Total impurities≤0.5% |
0.45% |
|
Residual solvents |
Ethanol≤3000ppm |
500ppm |
Tetrahydrofuran≤720ppm |
Not Detected |
|
Methylene chloride≤600ppm |
Not Detected |
|
Assay (HPLC) |
97.0~103.0% |
99.3% |
Conclusion |
The results conforms with EP7.0 standards |
Item |
Specifications |
Results |
Appearance |
White or almost white crystalline powder |
Conform |
Solubility |
Practically insoluble in water, soluble in acetone, sparingly soluble in alcohol, slightly soluble in methylene chloride |
Conform |
Identification |
IR spectrum of the sample corresponds to that of the reference standard |
Conform |
Melting point |
175~180℃ |
176~178℃ |
Specific rotation |
+76.0°~ +83.0° |
+77.8° |
Water |
2.9~3.5% |
3.0% |
Related substances |
Individual known impurity≤0.3% |
0.16% |
Any other impurity≤0.1% |
0.05% |
|
Total impurities≤0.5% |
0.45% |
|
Residual solvents |
Ethanol≤3000ppm |
500ppm |
Tetrahydrofuran≤720ppm |
Not Detected |
|
Methylene chloride≤600ppm |
Not Detected |
|
Assay (HPLC) |
97.0~103.0% |
99.3% |
Conclusion |
The results conforms with EP7.0 standards |
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