CAS NO:78919-13-8 ...

CAS NO:78919-13-8 ILOPROST
CAS NO:78919-13-8 ILOPROST
CAS NO:78919-13-8 ILOPROST

CAS NO:78919-13-8 ILOPROST

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1 Kilogram

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  • Min.Order :1 Kilogram
  • Purity: 98%
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Keywords

ILOPROST 78919-13-8 C22H32O4

Quick Details

  • Appearance:powder
  • Application:78919-13-8
  • PackAge:as requested
  • ProductionCapacity:300|Kilogram|Month
  • Storage:store in cool, dry place
  • Transportation:by sea or by air

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ILOPROST Basic information
Product Name: ILOPROST
Synonyms: (16r,s)-methyl-18,18,19,19-tetradehydro-6a-carbaprostaglandini(sub2);1h)-pentalenylidene)-;pentanoicacid,5-(hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1-octen-6-ynyl)-2(;zk36374;6,9ALPHA-METHYLENE-11ALPHA,15S-DIHYDROXY-16-METHYL-PROSTA-5E,13E-DIEN-18-YN-1-OIC ACID;CILOPROST;5-[Hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1-octen-6-ynyl)-2(1H)-pentalenylidene]pentanoic acid;Endoprost
CAS: 78919-13-8
MF: C22H32O4
MW: 360.49
EINECS:  
Product Categories: Chiral Reagents;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File: 78919-13-8.mol
ILOPROST Structure
 
ILOPROST Chemical Properties
storage temp.  Desiccate at -20°C
 
Safety Information
MSDS Information
 
 
ILOPROST Usage And Synthesis
Chemical Properties Colourless Oil
Usage A synthetic analogue of Prostacyclin (PGI2) used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud's phenomenon and ischemia. It acts through elevation of cAMP by binding to the prostacyclin receptor (IP receptor). Iloprost inhibits the ADP, thrombin, and collagen-induced aggregation of human platelets with an ED50 of about 13 nM. In whole animals, iloprost acts as a vasodilator, hypotensive, antidiuretic, and prolongs bleeding time.
Biological Activity Prostacyclin (PGI 2 ) analog that binds with high affinity to IP, EP 1 and EP 3 receptors (K i values are 11, 11, 56, 284, 619, 1035, 1870 and 6487 nM for IP, EP 1 , EP 3 , EP 4 , FP, DP, EP 2 and TP receptors respectively). Inhibits platelet aggregation induced by collagen, thrombin and ADP (IC 50 values are 0.24, 0.71 and 1.07 nM respectively).
 
ILOPROST Preparation Products And Raw materials
Raw materials Iloprost

 

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