Apigenin 520-36-5 98%MIN powder

Min.Order / FOB Price:Get Latest Price

1 Kilogram	FOB Price:USD 800.0000 -1000.0000

1 Kilogram

FOB Price:USD 800.0000 -1000.0000

Min.Order :1 Kilogram
Purity: 99% BY HPLC
Payment Terms : L/C,D/A,D/P,T/T,

Keywords

Apigenin 520-36-5 powder 520-36-5 98%MIN

Quick Details

Appearance:Solid powder
Application:Applied in dietary supplements,pharmaceutical or cosmeticeuticals
PackAge:Foil bag or drum
ProductionCapacity:5000|Metric Ton|Day
Storage:Sealed,light and oxygen resistant
Transportation:by sea or air

Superiority:

Apigenin 520-36-5 98%MIN powder

Kono Chem Co.,Ltd is a leading producer of standardized herbal extracts, natural active ingredients and APIs for pharmaceutical, health food and cosmetic industries.

Annually, more than 3,000 tons of a wide range of herbal extracts and natural active substances are extracted at the Kono Chem Co.,Ltd manufacturing plant near Xi'an, China. These extracts are in compliance with worldwide GMP、HACCP norms, international Pharmacopoeias, and international regulations.
The botanical raw materials are subject to strict selection and inspection, and extracts are manufactured according to methods developed by Kono Chem. They include inspections to guarantee a high quality standard from both analytico-chemical and therapeutic points of view, and take into consideration the state of art in different fields: research and development, analyses, processes and machinery, therapeutic applications on a scientific basis.

With our phytopharmaceutical background and knowledge through experience, Kono Chem can also provide a wide range of analytical services and reference substances to our clients. In addition, We also manufacture pharmaceutical raw materials of nucleotide species, mainly including as below: SAM-e Tosylate Disulfate; SAM-e 1,4-Butanedisulfonate; Polycytidylic Acid; Polyinosinic Acid; Adenosine Triphosphate Disodium; and Cytidine Triphosphate Disodium; these items are our strongest advantage in China. Meanwhile, we can do custom made pharmaceutical ingredients depending on our professional experts in the pharmaceutical and chemistry industry.

Recently, Kono Chem has been working hard on the research and development of new cardiovascular and anesthesia drugs, we have got good achievements; moreover, we also offer natural anticancer drugs and other pharmaceutical intermediates. As a GMP standardized manufacturer, our products can meet or even exceed the standards of CP2010, USP32, BP2005 and EP4. Presently, 80% and above of our products have been well-recognized in dozens of countries and regions, such as USA, EU, South America and Southeast Asia. There are experienced technicians working for our institutes now, all of them are skilled. Pioneer is looking forward to cooperating with friends all over the world for getting collaborative development; we are willing to work with you to develop new drugs and expand new business, let's work together for bright future.

Process Capability : Suoer critical CO2 extraction method Fermentation expert Other synthesis service

After-sale Service : Prompt delivery in worldwide 24 hour online Goods return policy

Superiority

pioneerbiotech is a leading manufacturer and supplier of chemicals in China. We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals and other fine chemicals.

We could give you:
1.Best quality in your requirement
2.Competitive price in China market
3.mature Technical support
4.Professional logistic support
All we want is win-win business. Send yr. inquiries, you will get it!

Details:

Specifications

1, free sample
2, prompt delivery
3, long -term stable supply
4, 8 years experence in the plant extract.

Product name	Celery Extract
Botanical Source	Apium graveolens
CAS NO.	520-36-5
Appearance	yellow fine powder
Capsaicinoids	98%
Test method	HPLC
Molecular formula:	C15H10O5
Molecular weight	270.25

Ash	≤2.0%
Loss on drying	≤5.0%
Color testing	≤0.11
Powder size	98% through 100 mesh
Heavy metals	≤10mg/kg
Iron	≤10mg/kg
Arsenic	≤2 mg/kg
Pesticides Residue
DDT	Non-detective
BHC	Non-detective
Solvent Residue
Methanol	Non-detective
Ethanol	≤1000mg/kg
Health Inspection
Total Aerobic	≤1000CFU/g
Mold and Yeast	≤100CFU/g
E.coli	Non-detective
Salmonella	Non-detective

Main Function : 1. Apigenin has potential to reduce the risk of cancer since it has anti-tumor activity . It can induce the apoptosis

of human gastric cancer cells via activating mitochondrial signal transdution pathway and promotes proliferative

inhibition and apoptotic induction of human acute myeloid leukaemia HL-60 cells by cisplatin (DDP)

2. Apigenin also could potentially be useful in allergic conditions since it can have anti-inflammatory properties .

3. Apigenin is a non-toxic plant flavonoid, has been shown to free radical scavenging properties and antioxidant

effects.

4. Apigenin is antiviral agents for the treatment of HIV and other infections .

Packing Detail:25kg/drum (25kg net weight,28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 350mm diameter) OR 1kg/bag (1kg net weight, 1.2kg gross weight, packed in an aluminum foil bag) OR as per your request.

Storage Situation:Stored in a cool and dry well-closed container kept away from moisture and strong light or high temperature.

Shelf Life:Two years under well Storage situation and stored away from direct sun light.

Reputable Factory Supply Quality 520-36-5 In Bulk Supply

Molecular Formula:C15H10O5
Molecular Weight:270.241
Appearance/Colour:Pale Yellow Crystalline Solid
Vapor Pressure:6E-13mmHg at 25°C
Melting Point:345-350 °C
Refractive Index:1.732
Boiling Point:555.5 °C at 760 mmHg
PKA:6.53±0.40(Predicted)
Flash Point:217 °C
PSA：90.90000
Density:1.548 g/cm³
LogP:2.57680

Apigenin(Cas 520-36-5) Usage

Preparation	4-hydroxybenzaldehyde (1.22 g, 9.97 mmol, 1.0 equiv) was added to asolution of 50% KOH (aq.) (6.72 g, 59.82 mmol, 6.0 equiv) and ethanol (3 mL) andstirred for 10 min. Then compound 9 (2.02g, 9.97 mmol, 1.0 equiv) was added to the reaction mixture and heated to 60 °C and stirred for 4 h. After cooled toroom temperature, the mixture was poured into ice water and acidified withconcentrated hydrochloric acid to pH = 3. Then the suspension was filtrated, washed and the residue was dried toafford Apigenin(2.43 g, 90%) as a red solid.
Anticancer Research	It induces apoptosis by targeting leptin/leptin receptor pathway and by targeting caspase-dependent extrinsic pathway aswell as STAT3 signaling pathway in lung adenocarcinoma and BT-474 breast cancercells, respectively. It shows antitumor activity against breastcancer MCF-7 cells and colon cancer HCT 116 cells and is a mediator of cancerchemoprevention and an inducer of autophagy. It can be used to treat colon canceras it induces apoptosis in colon cancer cells. It also increase melanogenesis in B16cells by activating the p38 MAPK pathway.
Purification Methods	The current method for the purification of apigenin is crude-solvent extraction method by using solvent in small quantity and also time saving. Apigenin that was isolated from Symphyotrichum novae-angliae was obtained in large quantity and directly from extract.

InChI:InChI=1/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H

520-36-5 Relevant articles

-

Dranik

, (1970)

Biotransformation of chrysin and apigenin by Cunninghamella elegans

Ibrahim, Abdel-Rahim Sayed

, p. 671 - 673 (2005)

Biotransformation of chrysin by Cunningh...

Regioselective ortho-Hydroxylations of Flavonoids by Yeast

Sordon, Sandra,Madej, Anna,Pop?oński, Jaros?aw,Bartmańska, Agnieszka,Tronina, Tomasz,Brzezowska, Ewa,Juszczyk, Piotr,Huszcza, Ewa

, p. 5525 - 5530 (2016)

Natural flavonoids, such as naringenin, ...

New Flavonoid Glycoside from Thalictrum minus

Komilov,Agzamova,Isaev,Eshbakova

, (2020)

The new flavonoid diglycoside thamiflasi...

Secondary metabolites of an Algerian Phlomis bovei and their antioxidant activities

Zaabat,Akkal,Darboure,Laouer,Franca, M. G. Dijoux,Duddeck, Helmut

, p. 454 - 455 (2010)

A new flavonoid glycoside from the leaf of Cephalotaxus koreana

Bae, KiHwan,Jin, WenYi,Thuong, Phuong Thien,Min, Byung Sun,Na, MinKyun,Lee, Young Mi,Kang, Sam Sik

, p. 409 - 413 (2007)

A new flavone glycoside, apigenin 5-O-α-...

-

Gusev et al.

, (1977)

Cloning of parsley flavone synthase I

Martens, Stefan,Forkmann, Gert,Matern, Ulrich,Lukacin, Richard

, p. 43 - 46 (2001)

A cDNA encoding flavone synthase I was a...

FLAVONOID GLYCOSIDES OF ARTEMISIA MONOSPERMA AND A. HERBA-ALBA

Saleh, Nabiel A. M.,El-Negoumy, Sabry I.,Abd-Alla, Mohamed F.,Abou-Zaid, Mamdouh M.,Dellamonica, G.,Chopin, J.

, p. 201 - 203 (1985)

Ten flavonoid glycosides were isolated a...

-

Zykova,Pivenko

, (1975)

A NEW GLYCOSYLATED FLAVONOID, 7-O-α-L-RHAMNOPYRANOSYL-4'-O-RUTINOSYLAPIGENIN, IN THE EXUDATE FROM GERMINATING SEEDS OF Sesbania rostrata

Messems, Eric,Montagu, Marc Van,Bruyn, Andre De,Jans, Arnold W. H.

, p. 241 - 254 (1989)

The title apigenin triglycoside was isol...

COSMETIC COMPOSITION FOR SKIN IMPROVEMENT COMPRISING GREEN BARLEY EXTRACT

-

, (2022/02/05)

Provided is a cosmetic composition for s...

Studies on Bignoniaceae: Newbouldiosides D-F, Minor Phenylethanoid Glycosides from Newbouldia laevis, and New Flavonoids from Markhamia zanzibarica and Spathodea campanulata

Kolodziej, Herbert

, p. 989 - 997 (2020/11/18)

Continued examination of the stem bark o...

Continuous flow microchannel synthesis process of flavonoid compounds

-

Paragraph 0050-0060, (2021/06/22)

The invention provides a continuous flow...

Extraction, Isolation and Characterization of Valuable Worked on Acacia Tortilis

Muhaisen, Hasan M. H.

, p. 6731 - 6747 (2021/11/01)

Acacia tortilis is one of the important ...

520-36-5 Process route

: apigenin-7-O-(β-D-apiofuranosyl-(1→2)-α-L-rhamnopyranozide)

: 639-97-4,6477-44-7,42927-70-8
D-apiose

: 3615-41-6,478518-52-4
L-Rhamnose

: 520-36-5
5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

Conditions

Conditions	Yield
With hydrogenchloride; In methanol; for 2h; Reflux;	2.5 mg

: 480-41-1
5,7-Dihydroxy-2-(4-hydroxy-phenyl)-chroman-4-on

: 520-36-5
5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

: 4049-38-1
eriodictyol