CasNo.520-18-3,Kaempferol 520-18-3 on hot sale manufacturer,(520-18-3) Suppliers

1 Kilogram	FOB Price:USD 800.0000 -1000.0000

Min.Order :1 Kilogram
Purity: 99% BY HPLC
Payment Terms : L/C,D/A,D/P,T/T,

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Kaempferol 520-18-3 manufacturer 520-18-3 on hot sale

Quick Details

Appearance:Solid powder
Application:Applied in dietary supplements,pharmaceutical or cosmeticeuticals
PackAge:Foil bag or drum
ProductionCapacity:5000|Kilogram|Day
Storage:Sealed,light and oxygen resistant
Transportation:by sea or air

Superiority:

Kaempferol 520-18-3

Kaempferol, is used as an inhibitor of Fatty Acid Synthase, Cox-1 activity, and Topo I. It also Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells.

Kaempferol is a naturally occurring flavonoid shown to act as a potent reversible inhibitor of Fatty Acid Synthase. Flavonoids have radical scavenging activity. Studies demonstrate that Kaempferol induces apoptosis in cancer cell lines and PC12 cell research reports Kaempferol to protect against oxidative stress-induced cytotoxicity. Additionally, Kaempferol has been shown to have a neuroprotective effect and represses the advancement of allergic inflammation mediated by IgE in difference cell models. A study which compared the CYP246 activity of Galangin (sc-235240), quercetin (sc-206089), and Kaempferol revealed that Kaempferol was the least potent flavanoid, with quercetin having the highest potency. Kaempferol acts as an inhibitor of Cox-1 activity (IC₅₀ = 180 μM) and inhibits Topo I catalyzed DNA religation in HL-60 cells. Kaempferol is an inhibitor of MAO.

Details:

Activates the mitochondrial Ca²⁺ uniporter (EC₅₀ = 7 μM). Induces caspase-9-mediated apoptosis in cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser¹⁰ phosphorylation in mouse epidermal JB6 C141 cells. Activates transcriptional coactivator with PDZ-binding motif (TAZ) and increases osteoblast differentiation of mesenchymal stem cells while inhibiting adipocyte differentiation. Naturally occurring flavonoid found in Gingko biloba and red wine.

Alternate Name	3,4′,5,7-Tetrahydroxyflavone, 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, Robigenin
Appearance	Yellow solid
CAS #	520-18-3
Molecular Formula	C??H??O?
Molecular Weight	286.24
Purity	≥95% by HPLC
Solubility	DMSO (25 mg/ml) or EtOH (20 mg/ml)
SMILES	C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O
InChi	InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
InChi Key	IYRMWMYZSQPJKC-UHFFFAOYSA-N
PubChem CID	5280863
MDL Number	MFCD00016938
Handling	Protect from air and light
Storage Conditions	-20°C
Shipping Conditions	Gel Pack
USAGE	For Research Use Only! Not For Use in Humans.