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Cabergoline 6-allyl-n-[3-(dimethylamino)propyl]-n-(ethylcarbamoyl)ergoline-8-carboxamide 81409-90-7
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Cabergoline 81409-90-7 Chemical Properties
mp 102-104°C
storage temp. Store at +4°C
CAS DataBase Reference 81409-90-7(CAS DataBase Reference)
Cabergoline 81409-90-7 Basic information
Product Name: Cabergoline
Synonyms: 6-allyl-n-[3-(dimethylamino)propyl]-n-(ethylcarbamoyl)ergoline-8-carboxamide;CABERGOLINE;(8-beta)-(2-propenyl);n-(3-(dimethylamino)propyl)-n-((ethylamino)carbonyl)-6-ergoline-8-carboxamid;FCE-21336,Cabaser,Dostinex;(8b)-N-[3-(Dimethylamino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propen-1-yl)- ergoline-8-carboxamide;Cabaser;Dostine
CAS: 81409-90-7
MF: C26H37N5O2
MW: 451.6
EINECS:
Product Categories: Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals;API
Mol File: 81409-90-7.mol
COA OF Cabergoline 81409-90-7
Item |
Specifications |
Results |
Description |
White or almost white crystalline powder |
Conform |
Identity |
1,IR complies |
Conform |
2,X-Ray complies |
Conform |
|
3,HPLC complies |
Conform |
|
Optical rotation |
-77.0°~-83.0° |
-78.0° |
Loss on drying |
Not more than 0.5% |
0.32% |
Related substances |
1,Cabergolin Imp A no more than0.15% |
0.05% |
2,Allylamide no more than 0.10% |
0.03% |
|
3,Allyl DHLA no more than 0.15% |
0.06% |
|
4,Cabergoline oxide no more than 0.10% |
0.04% |
|
5,Other impurities individually no more than 0.10% |
0.03% |
|
6,Total no more than 0.50% |
0.21% |
|
Assay(HPLC) |
98.0%~102.0%(recalculated on anhydrous basis) |
99.4% |
Residual solvents |
1,Dichloromethane no more than 100ppm |
15ppm |
2,Acetone no more than 200ppm |
15ppm |
|
3,Tert-butylmethylether no more than 200ppm |
11ppm |
|
4,Xylene no more than 1500ppm |
135ppm |
|
5,Heptane no more than 1000ppm |
20ppm |
|
Residue on ignition |
No more than0.10% |
0.03% |
Heavy metals |
No more than 20ppm |
1ppm |
Particle size |
90% of particles no more than 80um |
Conform |
Bulk density |
0.20~0.35g/cm3 |
0.33g/cm3 |
Conclusion |
The results conforms with EP7.0/USP38 standard. |
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