- Min.Order :1 Kilogram
- Purity: 98%
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Keywords
Pranlukast 103177-37-3 C27H23N5O4
Quick Details
- Appearance:powder
- Application:103177-37-3
- PackAge:as requested
- ProductionCapacity:300|Kilogram|Month
- Storage:store in cool, dry place
- Transportation:by sea or by air
Superiority:
| Pranlukast Basic information |
| Product Name: | Pranlukast |
| Synonyms: | PRANLUKAST;4-oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4h-1-benzopyranh;benzamide,n-(4-oxo-2-(1h-tetrazol-5-yl)-4h-1-benzopyran-8-yl)-4-(4-phenylbutox;emihydrate;hemihydrate;n-(4-oxo-2-(1h-tetrazol-5-yl)-4h-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzam;ono1078;rs411 |
| CAS: | 103177-37-3 |
| MF: | C27H23N5O4 |
| MW: | 481.5 |
| EINECS: | 201-616-4 |
| Product Categories: | Antiasthmatic;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;Heterocycles;API |
| Mol File: | 103177-37-3.mol |
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| Pranlukast Chemical Properties |
| Melting point | 236-238°C |
| storage temp. | Store at +4°C |
| CAS DataBase Reference | 103177-37-3(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | F,C |
| Risk Statements | 11-34 |
| Safety Statements | 16-26-36/37/39-45 |
| Pranlukast Usage And Synthesis |
| Asthma drugs |
Pranlukast is a common respiratory drug, it belongs to asthma drugs , it is the cysteinyl leukotrienes (LTs) receptor antagonist and it can bind to LTC4, LTD4, LTE4 receptors selectively to antagonize their effect . Roles and application are similar to zafirlukast. It is clinically used for the prevention of bronchial asthma. Oral 225mg once, 2 times one day, morning and evening after meal. After taking ,there may be gastrointestinal reactions,or there may be nausea, vomiting, abdominal pain, diarrhea or constipation, sometimes , fever, rash, pruritus and liver function abnormalities such as serum aminotransferase or bilirubin increase are visible . Pregnant women should use with caution , the elderly should take appropriate reductions. This product can not alleviate the onset of asthma. At present, three leukotriene receptor antagonists are used for the following purposes: 1, zafirlukast :it is effective for mild to moderate asthma ,it can cause improvement in dose-dependent lung function, and reduce the amount of β agonists. Absorption of the product is affected by food, it should not be taken together with food. Oral each 20mg, 2 times / d. 2, montelukast: it is valid for intermittent or persistent asthma in adults and children. This product is approved by the FDA for the treatment of children aged 6 to 12. Absorption of the product is not affected by food, it can be taken with food . Oral each 10mg, once / d. 3, pranlukast :it is used for mild to moderate asthma, pranlukast can increase patients maximum expiratory flow,and improve asthma symptoms, it can be used as a daily treatment of chronic asthma. Each oral 450mg, 2 times / d. The above information is edited by the chemicalbook of Tian Ye. |
| Chemical Properties | Off-white solid |
| Usage | A potent, selective and orally active CysLT receptor antagonist. Leukotriene antagonist. Used as an antiasthmatic |
| Usage | antiasthmatic;leukotriene receptor-1 antagonist |
| Usage | Labeled Pranlukast, intended for use as an internal standard for the quantification of Pranlukast by GC- or LC-mass spectrometry. |
| Biological Activity | Selective cysteinyl leukotriene receptor 1 (CysLT 1 ) antagonist (IC 50 values are ~ 4-7 and 3620 nM for CysLT 1 and CysLT 2 respectively). Inhibits contraction of airway smooth muscle, microvascular leakage into airways and eosinophil infiltration. Can decrease symptoms of bronchial asthma. |
| Pranlukast Preparation Products And Raw materials |
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