high quality of 2068-78-2 Vincristine sulfate factory

high quality of 2068-78-2 Vincristine sulfate factory

Min.Order / FOB Price:Get Latest Price

1 Kilogram	FOB Price:USD 10.0000 -100.0000

1 Kilogram

FOB Price:USD 10.0000 -100.0000

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : L/C,D/A,D/P,T/T,

Keywords

Vincristine sulfate Vincristine sulfate factory high quality of 2068-78-2

Quick Details

Appearance:White to slightly yellow
Application:Used for preparation of Vincristine Sulfate for Injection. Storage: Preserve in tightly closed containers, stored in a cool place and protected from Pharmaceutical raw materials, Oncology drug.
PackAge:25kg/carton drum(32cm*58cm)or 1kg/foil bag(10cm*15cm) or by request of clients
ProductionCapacity:5000|Kilogram|Month
Storage:Stored in sealed containers at a clean, cool & dry area. Keep away from light, moisture and pest infestation
Transportation:By sea or By air

Superiority:

Vincristine is an antimitotic vinca alkaloid, isolated from the plant V. rosea. It irreversibly blocks mitosis by binding to tubulin (K_i = 85 nM) and inhibiting tubulin polymerization.Vincristine is exported from cells via the ATP-binding cassette transporter P-glycoprotein, but not by multidrug resistance-associated protein. Its effectiveness in blocking the proliferation of cancer cells is affected by overexpression of P-glycoprotein.

Vincristine Sulfate is a kind of microtubule function inhibitor with IC50 of 10.4±1.1, 28.1±3.4, 22.4±2.1 µM for HL-60, Bel7402, HO-8910, respectively. It is the sulfate salt of a natural alkaloid isolated from the plant Vinca rosea Linn with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. The IC50 and IC90 of vincristine for the 4 vaccine-associated feline sarcoma (VAFS) cell lines were between 0.005 to 0.039 µg/ml and 0.045 to 1.027 µg/ml, respectively .This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism.

Details:

Vincristine sulfate is the sulfate salt of a natural alkaloid isolated from the periwinkle plant of the oleander family with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.

Product name
Vincristine sulfate salt, Microtubule inhibitor
Description

Microtubule inhibitor
Biological description

Anticancer agent; microtubule depolymerizer.
Purity

> 96%
CAS Number

2068-78-2
Chemical structure

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