favourable price of 302-79-4 Tretinoin top quality factory

favourable price of 302-79-4 Tretinoin top quality factory

Min.Order / FOB Price:Get Latest Price

1 Kilogram	FOB Price:USD 500.0000 -508.0000

1 Kilogram

FOB Price:USD 500.0000 -508.0000

Min.Order :1 Kilogram
Purity: 99.90%
Payment Terms : T/T,,MoneyGram,Other

Keywords

favourable price of 302-79-4 Tretinoin top quality Tretinoin factory

Quick Details

Appearance:solid or liquid
Application:for pharma use
PackAge:drum and bag
ProductionCapacity:5000|Kilogram|Month
Storage:in sealed air resistant place
Transportation:by sea or air

Superiority:

all-trans Retinoic acid is a metabolite of vitamin A and a ligand for retinoic acid receptors (RARs) with IC₅₀ values of 9, 3, and 10 nM for RARα, RARβ, and RARγ, respectively, in radioligand binding assays. It induces expression of a luciferase reporter in COS-7 cells expressing RARα, RARβ, or RARγ (EC₅₀s = 169, 9, and 2 nM, respectively). all-trans Retinoic acid reduces papilloma formation induced by phorbol 12-myristate 13-acetate in mice. It reduces bile duct proliferation, hydroxyproline levels, and liver inflammation in a rat model of α-naphthylisothiocyanate-induced chronic cholestasis and reduces plasma levels of alkaline phosphatase and bile salts in the Mdr2^-/- mouse model of cholestasis. all-trans Retinoic acid also reduces hepatic fat accumulation, triglycerides, body weight, and serum glucose levels in mice with Western diet-induced obesity.

Retinoic acid is an endogenous agonist for retinoic acid receptors (IC₅₀ = 14 nM for RARα, RARβ and RARγ receptors). Also promotes differentiation of mouse embryonic stem cells (ESCs) into adipocytes, neurons and glia in vitro. Proposed ligand of RORβ (K_d = 280 nM). Activates autophagy.

Details:

Retinoic acid is used in dermatology drugs. It is used in the treatment of psoriasis, ichthyosis, follicular keratosis, acne, lichen planus, verrucous epidermal nevus and lichen psoriasis. It is also employed in promoting the proliferation and differentiation of epithelial cells. In addition to this, it exhibits some preventive effect on skin cancer.

Alternate Name	ATRA; Tretinoin; NSC 122758; Vitamin A Acid; all-trans Retinoic Acid; NSC 122578
Appearance	Yellow solid with an orange tinge
CAS #	302-79-4
Molecular Formula	C??H??O?
Molecular Weight	300.44
Purity	≥98% by titration
Solubility	DMSO (20 mg/ml) or Ethanol (0.5 mg/ml)
SMILES	CC1=C(C(CCC1)(C)C)C=CC(=CC=CC(=CC(=O)O)C)C
InChi	InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+
InChi Key	SHGAZHPCJJPHSC-YCNIQYBTSA-N
PubChem CID	444795
MDL Number	MFCD00001551
Handling	Protect from air and light
Storage Conditions	-20°C
Shipping Conditions	Gel Pack
USAGE	For Research Use Only! Not For Use in Humans.

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