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L-dopa powder L-dopa 98%MIN 59-92-7 manufacturer
3,4-dihydroxy-L-phenylalanine (DOPA) is used as a cell adhesion molecule in serum-free cultures of anchorage-dependent mammalian cells. It is also used as an anticholinergic drug and used in the treatment of Parkinson's disease. It acts as an intermediate in the biosynthesis of other catecholamines (norepinephrine, epinephrine) and melanin. It acts as a precursor of dopamine product of tyrosine hydroxylase
Dopamine is a neurotransmitter involved in synaptic plasticity, cognition, and the regulation of locomotor control. It is produced endogenously in the substantia nigra and ventral tegmental area but when administered exogenously cannot cross the blood brain barrier. L-DOPA is a metabolic precursor of dopamine that is capable of crossing the blood brain barrier.1 It is produced from L-tyrosine by tyrosine hydroxylase and metabolized by catechol-O-methyl transferase (COMT). In the brain L-DOPA is converted to dopamine. Formulations containing L-DOPA have been used to increase dopamine concentrations in the brain as a treatment for Parkinson’s disease and stroke recovery.
Catalogue Number | D533751 |
Chemical Name | L-DOPA |
Synonyms | Levodopa; L-3-Hydroxytyrosine; 3-Hydroxy-L-tyrosine; (-)-3-(3,4-Dihydroxyphenyl)-L-alanine; Bendopa; Deadopa; Dopaflex; Dopal; Dopaidan; Dopalina; Dopar; |
CAS Number | 59-92-7 |
Molecular Formula | C?H??NO? |
Appearance | White to Off-White Solid |
Melting Point | >245°C (dec.) |
Molecular Weight | 197.19 |
Storage | -20°C Freezer |
Solubility | Aqueous Acid (Slightly), Water (Slightly, Heated) |
Category | Standards; Chiral Molecules; Amino Acids; Neurochemicals; Pharmaceutical/API Drug Impurities/Metabolites; |
Applications | Natural isomer of the immediate precursor of dopamine; product of tyrsine hydroxylase. |
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