Cabozantinib Malate

Cabozantinib Malate
Cabozantinib Malate
Cabozantinib Malate

Cabozantinib Malate

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1 Kilogram

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Keywords

Cabozantinib Malate 1140909-48-3 C32H30FN3O10

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  • Appearance:powder
  • Application:1140909-48-3
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  • ProductionCapacity:300|Kilogram|Month
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Cabozantinib Malate Basic information
Product Name: Cabozantinib Malate
Synonyms: (2S)-2-Hydroxybutanedioic acid compd. with N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (1:1);Cabozantinib (S)-malate;Cabozantinib L-Malate Salt;N-[4-[(6,7-DiMethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxaMide (2S)-;Cabozantinib (S)-Malate(XL-184);Cabozantinib L-Malate;Cabozantinib Malate (XL184);XL-184 (Malate)
CAS: 1140909-48-3
MF: C32H30FN3O10
MW: 635.5931032
EINECS:  
Product Categories: Inhibitors
Mol File: 1140909-48-3.mol
Cabozantinib Malate Structure
 
Cabozantinib Malate Chemical Properties
 
Safety Information
MSDS Information
 
 
Cabozantinib Malate Usage And Synthesis
Chemical Properties Off-White Solid
Usage Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell a poptosis.
Usage XL184 (Cabozantinib, BMS-907351) is a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively.
Usage Cabozantinib malate is the malate of Cabozantinib, a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.
 
Cabozantinib Malate Preparation Products And Raw materials

 

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