Raloxifene

Raloxifene
Raloxifene
Raloxifene
Raloxifene

Raloxifene

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1 Kilogram

Negotiable

  • Min.Order :1 Kilogram
  • Purity: 99%
  • Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Raloxifene 84449-90-1 C28H27NO4S

Quick Details

  • Appearance:Light-Yellow Solid
  • Application:84449-90-1
  • PackAge:As requested
  • ProductionCapacity:300|Kilogram|Day
  • Storage:desiccate at +4°C
  • Transportation:By air or by sea

Superiority:

Raloxifene Basic information
Product Name: Raloxifene
Synonyms: RALOXIFEN;RALOXIFENE;[4-[2-(1-Piperidinyl) Ethoxy] Phenyl]methanone.HCL;RALOXAFINE;[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone;[6-hydroxy-2-(4-hydroxyphenyl)benzothiophen-3-yl]-[4-[2-(1-piperidyl)ethoxy]phenyl]methanone hydrochloride;[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-y1][4-[2-(1-piperidinyl)ethoxy]phenyl]methamone;Evista
CAS: 84449-90-1
MF: C28H27NO4S
MW: 473.58
EINECS:  
Product Categories: Raloxifene;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate
Mol File: 84449-90-1.mol
Raloxifene Structure
 
Raloxifene Chemical Properties
Melting point  250-253°C
storage temp.  Desiccate at +4°C
solubility  DMSO: 28 mg/mL, soluble
form  solid
color  light yellow
CAS DataBase Reference 84449-90-1(CAS DataBase Reference)
 
Safety Information
WGK Germany  3
Hazardous Substances Data 84449-90-1(Hazardous Substances Data)
 
Raloxifene Usage And Synthesis
Chemical Properties Light-Yellow Solid
Usage A nonsteroidal estrogen receptor mixed agonist/antagonist
Definition ChEBI: A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively.
Biological Activity Selective estrogen receptor modulator (SERM) that binds to ER α and ER β , and tissue-dependently activates or blocks estrogen-induced transcription. Acts as an antiestrogen in breast and uterine tissue, but displays estrogen agonist activity in bone. In D12 rat hypothalamic cells, inhibits progesterone receptor induction by estrogen with an IC 50 of 1 nM.
 
Raloxifene Preparation Products And Raw materials
Raw materials Methanesulfonyl chloride-->Biphenyl-->Thianaphthene-->2-Bromo-4'-methoxyacetophenone-->Phenetole

 

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