KU-55933 (ATM Kinas...

KU-55933 (ATM Kinase Inhibitor)
KU-55933 (ATM Kinase Inhibitor)
KU-55933 (ATM Kinase Inhibitor)

KU-55933 (ATM Kinase Inhibitor)

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1 Kilogram

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KU-55933 (ATM Kinase Inhibitor) 587871-26-9 C21H17NO3S2

Quick Details

  • Appearance:powder
  • Application:587871-26-9
  • PackAge:As requested
  • ProductionCapacity:300|Kilogram|Day
  • Storage:Desiccate at -20°C
  • Transportation:By air or by sea

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KU-55933 (ATM Kinase Inhibitor) Basic information
Product Name: KU-55933 (ATM Kinase Inhibitor)
Synonyms: 2-MORPHOLIN-4-YL-6-THIANTHREN-1-YL-PYRAN-4-ONE;2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one;KU-55933 (ATM Kinase Inhibitor);KU-55933, >99%;KV-55933;2-morpholino-6-(thianthren-1-yl)-4H-pyran-4-one;2-Morpholin-4-yl-6-thianthren-1-ylpyran-4-one KU-55933 (ATM Kinase Inhibitor);KU 55933, >=98%
CAS: 587871-26-9
MF: C21H17NO3S2
MW: 395.49
EINECS:  
Product Categories: Inhibitors
Mol File: 587871-26-9.mol
KU-55933 (ATM Kinase Inhibitor) Structure
 
KU-55933 (ATM Kinase Inhibitor) Chemical Properties
storage temp.  Desiccate at -20°C
 
KU-55933 (ATM Kinase Inhibitor) Usage And Synthesis
Usage A potent and specific ATM kinase inhibitor with an IC50 and a Ki of 13 nM and 2.2 nM, respectively.
Biological Activity Potent, selective and competitive ATM kinase inhibitor (K i = 2.2 nM, IC 50 values are 13, 2500, 9300, 16600, > 100000 and > 100000 nM at ATM, DNA-PK, mTOR, PI 3-kinase, PI 4-K and ATR respectively). Decreases viability of MCF-7, A549 and HCT116 cells and decreases p21 CIP1 levels in vitro . Acts as a radio- and chemosensitizer for the treatment of cancer.

 

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