MITHRAMYCIN A

MITHRAMYCIN A
MITHRAMYCIN A
MITHRAMYCIN A

MITHRAMYCIN A

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1 Kilogram

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  • Purity: 90%
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MITHRAMYCIN A 18378-89-7 C52H76O24

Quick Details

  • Appearance:yellow powder
  • Application:18378-89-7
  • PackAge:As requested
  • ProductionCapacity:300|Kilogram|Day
  • Storage:2-8°C
  • Transportation:By air or by sea

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MITHRAMYCIN A Basic information
Product Name: MITHRAMYCIN A
Synonyms: AUREOLIC ACID;METHRAMYCIN A;MITHRACIN;MITHRAMYCIN;MITHRAMYCIN A;MITHRAMYCIN A, STREPTOMYCES PLICATUS;PLICAMYCIN;(2s-alpha,3beta(1r*,3r*4s*)))-droxy-7-methyl
CAS: 18378-89-7
MF: C52H76O24
MW: 1085.15
EINECS: 232-455-8
Product Categories: Antibiotics;Antitumour;antibiotic
Mol File: 18378-89-7.mol
MITHRAMYCIN A Structure
 
MITHRAMYCIN A Chemical Properties
Melting point  180-183 °C
storage temp.  2-8°C
Merck  13,7619
 
Safety Information
Hazard Codes  Xn,T+
Risk Statements  22-26/27/28
Safety Statements  45-38-36/37/39-28A-22
RIDADR  3249
WGK Germany  3
RTECS  PZ2800000
F  10
HazardClass  6.1(b)
PackingGroup  III
 
MITHRAMYCIN A Usage And Synthesis
Chemical Properties yellow powder
Usage Transcription inhibitor
Usage Mithramycin was the first of the aureolic acid class of antitumour antibiotics, isolated from Streptomyces. Mithramycin inhibits transcription and protein synthesis by non-covalent binding with G-C-rich duplex DNA in the presence of magnesium and zinc ions. Mithramycin also induces differentiation of leukemic cells accompanied by an early decrease in c-myc expression, and selectively inhibits collagen-1 gene expression in human fibroblasts.
Usage Mithramycin A was the first of the aureolic acid class of antitumor antibiotics, isolated from Streptomyces. Mithramycin inhibits transcription and protein synthesis by non-covalent binding with G-C-rich duplex DNA in the presence of magnesium and zinc ions. Mithramycin also induces differentiation of leukemic cells accompanied by an early decrease in c-myc expression, and selectively inhibits collagen-1 gene expression in human fibroblasts.
Biological Activity Anticancer antibiotic that selectively binds to G-C-rich DNA in the presence of Mg 2+ or Zn 2+ , inhibiting RNA and DNA polymerase action. Inhibits c-myc expression and induces myeloid differentiation of HL-60 promyelocytic leukemia cells.

 

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