DAPT

DAPT
DAPT
DAPT

DAPT

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1 Kilogram

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  • Min.Order :1 Kilogram
  • Purity: 99%
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Keywords

DAPT 208255-80-5 C23H26F2N2O4

Quick Details

  • Appearance:powder
  • Application:208255-80-5
  • PackAge:As requested
  • ProductionCapacity:300|Kilogram|Day
  • Storage:2-8°C
  • Transportation:By air or by sea

Superiority:

 
DAPT Basic information
Product Name: DAPT
Synonyms: LY-374973, N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester;γ-Secretase Inhibitor IX;N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethylester;SC-201315;(2S)-N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-2-phenylglycine tert-butyl ester;DAPT (enzyme inhibitor);GSI-IX;DAPT (GSI-IX)
CAS: 208255-80-5
MF: C23H26F2N2O4
MW: 432.464
EINECS:  
Product Categories: Angiogenesis and Metastasis;Protease inhibitor;Inhibitor;GSI-IX;Inhibitors
Mol File: 208255-80-5.mol
DAPT Structure
 
DAPT Chemical Properties
density  1.213
storage temp.  2-8°C
solubility  DMSO: ~18 mg/mL
form  solid
color  white
 
Safety Information
WGK Germany  3
 
DAPT Usage And Synthesis
Usage DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells
Biological Activity Inhibitor of γ -secretase; causes a reduction in A β 40 and A β 42 levels in human primary neuronal cultures (IC 50 values are 115 and 200 nM for total A β and A β 42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo . Does not effect APP α and APP β levels. Blocks Notch signaling in hybrid human-mouse foetal thymus organ culture (FTOC). Activity causes neural cells to commit to neuronal differentiation.

 

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