Cefsulodine sodium

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1 Kilogram	Negotiable

1 Kilogram

Negotiable

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Cefsulodine sodium 52152-93-9 C22H19N4O8S2.Na

Quick Details

Appearance:powder
Application:52152-93-9
PackAge:As requested
ProductionCapacity:300|Kilogram|Day
Storage:Ventilated, low-temperature ,dry storeroom.
Transportation:By air or by sea

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Cefsulodine sodium Basic information

Cephalosporins Category Toxicity grading Acute toxicity Flammability and hazard characteristics Storage Characteristics Extinguishing agent

Product Name:	Cefsulodine sodium
Synonyms:	(6r-(6-alpha,7-beta(r*)))-odiumsal;4-(aminocarbonyl)-1-((2-carboxy-8-oxo-7-((phenylsulfoacetyl)amino)-pyridiniu;5-thio-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-,hydroxide,innersalt,monos;abbott-46811;cefomonil;cetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-,innersalt,mono;cgp7174e;monaspor
CAS:	52152-93-9
MF:	C22H19N4O8S2.Na
MW:	554.53
EINECS:	257-692-4
Product Categories:	A - KResearch Essentials;Antibacterial;Antibiotics A to;Antibiotics A-FAntibiotics;AntibioticsAntibiotics;Chemical Structure Class;Core Bioreagents;Interferes with Cell Wall SynthesisAntibiotics;Mechanism of Action;Penicillins and Cephalosporins (beta-Lactams);Spectrum of Activity;GUBERNAL;antibiotic
Mol File:	52152-93-9.mol

Cefsulodine sodium Chemical Properties

Melting point	175 C
storage temp.	2-8°C
solubility	H₂O: 50 mg/mL, clear, light yellow
Merck	13,1958

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-42/43-20/21/22
Safety Statements	22-26-36/37-45-36
WGK Germany	2
RTECS	UU1785000

Cefsulodine sodium Usage And Synthesis

Cephalosporins	Cefsulodine sodium is a cephalosporin antibiotic, its antimicrobial spectrum is narrow, because it has good permeability to the outer layer of the cell wall of Pseudomonas aeruginosa , and it has a high affinity on penicillin-binding protein LA, LB and Ⅲ and thus it has strong bactericidal inhibition effect on the formation of the cell wall peptidoglycan , it has a strong and specific bactericidal effect on P. aeruginosa , the MIC is 1.5μg / ml, and it has high stability on β- lactamase produced by itself . Its antimicrobial activity against Pseudomonas aeruginosa is stronger than cefoperazone, methyl benzyl amoxicillin (10 times), carbenicillin, piperacillin and hydroxyl ampicillin (16 to 32-fold) , and its antimicrobial activity against Pseudomonas aeruginosa is equal to aminoglycoside antibiotics such as gentamicin, dibekacin . And there is no cross-resistance.After intramuscular or intravenous administration 0.5g, 15min respectively ,it achieves the maximum blood concentration of 37.2μg / ml, and the concentration of the drug increases with the increase of the dose . It can be quickly distributed to the kidneys, blood plasma, lung, heart, digestive tract, liver and spleen, and it can go access to sputum, wound exudate, amniotic fluid and breast milk. PBP is 70%, t1 / 2 is 1.5h, it is mainly excreted in the urine, 6h after treatment the urine excretion rate is 60% to 70%, metabolites with antibacterial activity are not found in the urine . In renal dysfunction patients , plasma concentration increases, half-life extends and urinary excretion rate decreases. Sodium cefsulodin is clinically used for the treatment of respiratory tract infections caused by Pseudomonas aeruginosa, pyelonephritis, cystitis, peritonitis, septicemia, prostatitis, burns, wounds and otitis media secondary infection, corneal ulcers, especially penicillin and aminoglycosides antibiotic treatment ineffective Pseudomonas aeruginosa infection. Adverse reactions occurring rate is approximately 1.3%, it is similar to other cephalosporins. Occasionally allergic reactions occur, such as rash, urticaria.There are gastrointestinal reactions. Injection site is painful, intravenous injection causes phlebitis, mildly elevated serum transaminases , few visible proteinuria; there are also visible thrombocytopenia, increased eosinophils; rare thrombocytopenia, vitamin deficiency and the like. Patients allergic to the chemicalsare are banned .Patients allergic to penicillin,and cephalosporin , having history of allergy diseases, allergic bodies, severe renal dysfunction, and pregnant women should use with caution. Cefsulodine sodium together with diuretics, aminoglycosides can increase renal toxicity. Check liver function, kidney function and blood at regular intervals . The above information is edited by the chemicalbook of Tian Ye.
Category	Toxic substances
Toxicity grading	Low toxicity
Acute toxicity	Intravenous - rat LD50: 3030 mg / kg; Intravenous - Mouse LD50: 3780 mg / kg.
Flammability and hazard characteristics	Thermal decomposition produces toxic nitrogen oxides, sulfur oxides, sodium oxide fumes.
Storage Characteristics	Ventilated, low-temperature ,dry storeroom.
Extinguishing agent	Water, carbon dioxide, foam, powder.
Usage	betaadrenergic blocker
Usage	Cefsulodin is a third generation cephalosporin (C258750) antibiotic designed specifically for Pseudomonas Aeruginosa.

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Cefsulodine sodium